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- Publisher Website: 10.1093/ehjci/jeab059
- Scopus: eid_2-s2.0-85127921029
- PMID: 33826731
- WOS: WOS:000755676800001
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Article: Prognostic value and reversibility of liver stiffness in patients undergoing tricuspid annuloplasty
Title | Prognostic value and reversibility of liver stiffness in patients undergoing tricuspid annuloplasty |
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Authors | |
Keywords | Liver stiffness Tricuspid annuloplasty Adverse outcome |
Issue Date | 2022 |
Publisher | Oxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org |
Citation | European Heart Journal - Cardiovascular Imaging, 2022, v. 23 n. 4, p. 551-559 How to Cite? |
Abstract | Background:
Liver stiffness (LS) assessed by transient elastography is associated with adverse events in patients with heart failure. However, the predictive value of LS for adverse outcome is uncertain in patients undergoing tricuspid annuloplasty (TA). This study sought to evaluate the prognostic value and reversibility of LS in patients undergoing TA during left-sided valve surgery.
Methods and results:
A total of 158 patients who underwent TA were prospectively evaluated. Patients were divided into three groups according to tertile of LS. Adverse outcome was defined as heart failure that required hospital admission or all-cause mortality following TA. The median LS was 13.9 (inter-quartile range 8.1–22.3) kPa and independently correlated positively with tricuspid regurgitation (TR) severity, inferior vena cava diameter and negatively with tricuspid annular plane systolic excursion. During a median follow-up of 31 months, 49 adverse events occurred. Multivariable Cox regression analysis revealed that LS was an independent predictor of adverse events. Significant improvement in LS at 1-year post-TA (13.1–7.8 kPa, P < 0.01) was noted only in patients who had no adverse events, not in those who experienced heart failure (17.1–14.2 kPa, P = 0.87) and seems to be linked to an absence of TR recurrence.
Conclusions:
This study demonstrated that LS is predictive of adverse outcome and is reversible in patients undergoing TA without TR recurrence at 1 year. These findings suggest that assessing LS, an integrative correlate of right heart condition, may aid the pre-operative risk assessment of candidate for heart surgery including TA. |
Persistent Identifier | http://hdl.handle.net/10722/304707 |
ISSN | 2023 Impact Factor: 6.7 2023 SCImago Journal Rankings: 3.011 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, Y | - |
dc.contributor.author | Chan, YH | - |
dc.contributor.author | Wu, MZ | - |
dc.contributor.author | Yu, YJ | - |
dc.contributor.author | Ren, QW | - |
dc.contributor.author | Lam, YM | - |
dc.contributor.author | Seto, WK | - |
dc.contributor.author | Yuen, MF | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Lau, CP | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Yiu, KH | - |
dc.date.accessioned | 2021-10-05T02:34:00Z | - |
dc.date.available | 2021-10-05T02:34:00Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | European Heart Journal - Cardiovascular Imaging, 2022, v. 23 n. 4, p. 551-559 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304707 | - |
dc.description.abstract | Background: Liver stiffness (LS) assessed by transient elastography is associated with adverse events in patients with heart failure. However, the predictive value of LS for adverse outcome is uncertain in patients undergoing tricuspid annuloplasty (TA). This study sought to evaluate the prognostic value and reversibility of LS in patients undergoing TA during left-sided valve surgery. Methods and results: A total of 158 patients who underwent TA were prospectively evaluated. Patients were divided into three groups according to tertile of LS. Adverse outcome was defined as heart failure that required hospital admission or all-cause mortality following TA. The median LS was 13.9 (inter-quartile range 8.1–22.3) kPa and independently correlated positively with tricuspid regurgitation (TR) severity, inferior vena cava diameter and negatively with tricuspid annular plane systolic excursion. During a median follow-up of 31 months, 49 adverse events occurred. Multivariable Cox regression analysis revealed that LS was an independent predictor of adverse events. Significant improvement in LS at 1-year post-TA (13.1–7.8 kPa, P < 0.01) was noted only in patients who had no adverse events, not in those who experienced heart failure (17.1–14.2 kPa, P = 0.87) and seems to be linked to an absence of TR recurrence. Conclusions: This study demonstrated that LS is predictive of adverse outcome and is reversible in patients undergoing TA without TR recurrence at 1 year. These findings suggest that assessing LS, an integrative correlate of right heart condition, may aid the pre-operative risk assessment of candidate for heart surgery including TA. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org | - |
dc.relation.ispartof | European Heart Journal - Cardiovascular Imaging | - |
dc.subject | Liver stiffness | - |
dc.subject | Tricuspid annuloplasty | - |
dc.subject | Adverse outcome | - |
dc.title | Prognostic value and reversibility of liver stiffness in patients undergoing tricuspid annuloplasty | - |
dc.type | Article | - |
dc.identifier.email | Chan, YH: chanwill@hku.hk | - |
dc.identifier.email | Lam, YM: lamym2@hku.hk | - |
dc.identifier.email | Seto, WK: wkseto@hku.hk | - |
dc.identifier.email | Yuen, MF: mfyuen@hku.hk | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.email | Lau, CP: cplau@hkucc.hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.authority | Chan, YH=rp01313 | - |
dc.identifier.authority | Seto, WK=rp01659 | - |
dc.identifier.authority | Yuen, MF=rp00479 | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/ehjci/jeab059 | - |
dc.identifier.pmid | 33826731 | - |
dc.identifier.scopus | eid_2-s2.0-85127921029 | - |
dc.identifier.hkuros | 326501 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 551 | - |
dc.identifier.epage | 559 | - |
dc.identifier.isi | WOS:000755676800001 | - |
dc.publisher.place | United Kingdom | - |