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- Publisher Website: 10.1109/EMBC44109.2020.9176013
- Scopus: eid_2-s2.0-85091031348
- PMID: 33018178
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Conference Paper: Early Detection of Amyloid β Pathology in Alzheimer’s Disease by Molecular MRI
Title | Early Detection of Amyloid β Pathology in Alzheimer’s Disease by Molecular MRI |
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Authors | |
Issue Date | 2020 |
Publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 |
Citation | Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 20-24 July 2020, p. 1100-1103 How to Cite? |
Abstract | Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia. Early stage β-amyloid oligomers (AβOs) and late stage Aβ plaques are the pathological hallmarks of AD brains. AβOs are known to be more neurotoxic and contribute to neuronal damage. Most current approaches are focused on detecting Aβ plaques, which occurs at the late stage of AD, and are limited by poor sensitivity and/or contrast agent toxicity. In previous studies, we developed a new curcumin-conjugated magnetic nanoparticle (Cur-MNPs) to target the Aβ pathologies. In this study, we investigate the in vivo feasibility of this novel Cur-MNPs to detect Aβ pathologies at the early and late stages of AD in transgenic AD mice and perform immunohistochemical examinations to validate the specific targeting of various form of Aβ pathologies. |
Persistent Identifier | http://hdl.handle.net/10722/304347 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Dong, CM | - |
dc.contributor.author | Guo, AS | - |
dc.contributor.author | To, A | - |
dc.contributor.author | Chan, KWY | - |
dc.contributor.author | Chow, ASF | - |
dc.contributor.author | Bian, L | - |
dc.contributor.author | Leong, TL | - |
dc.contributor.author | Wu, EX | - |
dc.date.accessioned | 2021-09-23T08:58:46Z | - |
dc.date.available | 2021-09-23T08:58:46Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 20-24 July 2020, p. 1100-1103 | - |
dc.identifier.issn | 2375-7477 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304347 | - |
dc.description.abstract | Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia. Early stage β-amyloid oligomers (AβOs) and late stage Aβ plaques are the pathological hallmarks of AD brains. AβOs are known to be more neurotoxic and contribute to neuronal damage. Most current approaches are focused on detecting Aβ plaques, which occurs at the late stage of AD, and are limited by poor sensitivity and/or contrast agent toxicity. In previous studies, we developed a new curcumin-conjugated magnetic nanoparticle (Cur-MNPs) to target the Aβ pathologies. In this study, we investigate the in vivo feasibility of this novel Cur-MNPs to detect Aβ pathologies at the early and late stages of AD in transgenic AD mice and perform immunohistochemical examinations to validate the specific targeting of various form of Aβ pathologies. | - |
dc.language | eng | - |
dc.publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 | - |
dc.relation.ispartof | 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) | - |
dc.rights | IEEE Engineering in Medicine and Biology Society (EMBC) Conference Proceedings. Copyright © Institute of Electrical and Electronics Engineers. | - |
dc.rights | ©2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | - |
dc.subject.mesh | Alzheimer Disease | - |
dc.subject.mesh | Amyloid beta-Peptides | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Early Diagnosis | - |
dc.subject.mesh | Magnetic Resonance Imaging | - |
dc.title | Early Detection of Amyloid β Pathology in Alzheimer’s Disease by Molecular MRI | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chow, ASF: asfchow@hku.hk | - |
dc.identifier.email | Leong, TL: tlleong@hku.hk | - |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
dc.identifier.authority | Chow, ASF=rp02296 | - |
dc.identifier.authority | Leong, TL=rp02483 | - |
dc.identifier.authority | Wu, EX=rp00193 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1109/EMBC44109.2020.9176013 | - |
dc.identifier.pmid | 33018178 | - |
dc.identifier.scopus | eid_2-s2.0-85091031348 | - |
dc.identifier.hkuros | 325446 | - |
dc.identifier.spage | 1100 | - |
dc.identifier.epage | 1103 | - |
dc.publisher.place | United States | - |