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- Publisher Website: 10.1186/s12916-021-01991-w
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- PMID: 34039350
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Article: Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome
Title | Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome |
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Authors | |
Keywords | Gestational diabetes mellitus Microbiota Metabolome |
Issue Date | 2021 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmed/ |
Citation | BMC Medicine, 2021, v. 19 n. 1, p. article no. 120 How to Cite? |
Abstract | Background:
Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabolome remains incompletely understood.
Methods:
Four hundred eighteen mothers (147 women with GDM and 271 normal pregnant women) and their neonates from the GDM Mother and Child Study were included in this study. Meconium microbiota were profiled by 16S rRNA gene sequencing. Meconium and maternal serum metabolome were examined by UPLC-QE.
Results:
Microbial communities in meconium were significantly altered in neonates from the GDM mothers. A reduction in alpha diversity was observed in neonates of GDM mothers. At the phylum level, the abundance of Firmicutes and Proteobacteria changed significantly in neonates of GDM mothers. Metabolomic analysis of meconium showed that metabolic pathways including taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis were altered in GDM subjects. Several changed metabolites varying by the similar trend across the maternal serum and neonatal meconium were observed.
Conclusion:
Altogether, these findings suggest that GDM could alter the serum metabolome and is associated with the neonatal meconium microbiota and metabolome, highlighting the importance of maternal factors on early-life metabolism. |
Persistent Identifier | http://hdl.handle.net/10722/301233 |
ISSN | 2023 Impact Factor: 7.0 2023 SCImago Journal Rankings: 2.711 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, T | - |
dc.contributor.author | Qin, Y | - |
dc.contributor.author | Chen, M | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Dong, T | - |
dc.contributor.author | Chen, G | - |
dc.contributor.author | Sun, X | - |
dc.contributor.author | Lu, T | - |
dc.contributor.author | White, RA | - |
dc.contributor.author | PENG, Y | - |
dc.contributor.author | Tun, HM | - |
dc.contributor.author | Xia, Y | - |
dc.date.accessioned | 2021-07-27T08:08:05Z | - |
dc.date.available | 2021-07-27T08:08:05Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | BMC Medicine, 2021, v. 19 n. 1, p. article no. 120 | - |
dc.identifier.issn | 1741-7015 | - |
dc.identifier.uri | http://hdl.handle.net/10722/301233 | - |
dc.description.abstract | Background: Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabolome remains incompletely understood. Methods: Four hundred eighteen mothers (147 women with GDM and 271 normal pregnant women) and their neonates from the GDM Mother and Child Study were included in this study. Meconium microbiota were profiled by 16S rRNA gene sequencing. Meconium and maternal serum metabolome were examined by UPLC-QE. Results: Microbial communities in meconium were significantly altered in neonates from the GDM mothers. A reduction in alpha diversity was observed in neonates of GDM mothers. At the phylum level, the abundance of Firmicutes and Proteobacteria changed significantly in neonates of GDM mothers. Metabolomic analysis of meconium showed that metabolic pathways including taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis were altered in GDM subjects. Several changed metabolites varying by the similar trend across the maternal serum and neonatal meconium were observed. Conclusion: Altogether, these findings suggest that GDM could alter the serum metabolome and is associated with the neonatal meconium microbiota and metabolome, highlighting the importance of maternal factors on early-life metabolism. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmed/ | - |
dc.relation.ispartof | BMC Medicine | - |
dc.rights | BMC Medicine. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Gestational diabetes mellitus | - |
dc.subject | Microbiota | - |
dc.subject | Metabolome | - |
dc.title | Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome | - |
dc.type | Article | - |
dc.identifier.email | Tun, HM: heinmtun@hku.hk | - |
dc.identifier.authority | Tun, HM=rp02389 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s12916-021-01991-w | - |
dc.identifier.pmid | 34039350 | - |
dc.identifier.pmcid | PMC8157751 | - |
dc.identifier.scopus | eid_2-s2.0-85106874961 | - |
dc.identifier.hkuros | 323435 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 120 | - |
dc.identifier.epage | article no. 120 | - |
dc.identifier.isi | WOS:000655092200001 | - |
dc.publisher.place | United Kingdom | - |