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Article: Standard management protocol to improve the short‐term outcome of biliary atresia

TitleStandard management protocol to improve the short‐term outcome of biliary atresia
Authors
Keywordsbiliary atresia
cholangitis
Kasai operation
liver transplant
Issue Date2020
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1754
Citation
Journal of Paediatrics and Child Health, 2020, v. 56 n. 11, p. 1774-1778 How to Cite?
AbstractAim: This study compared the outcomes of patients with biliary atresia (BA) treated according to a standardised protocol with historical patients. Methods: This is a single‐centred retrospective study of BA patients treated from 1980 to 2016. A standardised treatment protocol was established since 2008 regarding peri‐operative management. The outcomes being compared between the two groups (Groups I and II = before and after 2008, respectively) were jaundice clearance (JC), incidence of recurrent cholangitis, hospital admission and native liver survival (NLS). Results: A total of 128 patients were included (Group I = 100, Group II = 28). The overall median follow‐up period was 15.3 years (I vs. II = 20.6 years vs. 5.1 years, respectively). There was no significant difference in the JC at the sixth month between the two groups (I vs. II = 60.0 vs. 82.1%, respectively, P = 0.07). The incidence of recurrent cholangitis was similar between the two groups (I vs. II = 39 vs. 35.7%, respectively, P = 0.45), but the median hospital admission episode per patient was non‐significantly higher in Group I (I vs. II = 4.2 vs. 2.7, respectively, P = 0.08). There was an improvement in the 1‐year NLS rate in Group II (I vs. II = 69.0 vs. 85.7%, respectively, P = 0.05). Conclusions: The introduction of a standardised management protocol has improved the short‐term outcome of BA patients, with a better 1‐year NLS observed.
Persistent Identifierhttp://hdl.handle.net/10722/295370
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.499
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, PHY-
dc.contributor.authorWong, KKY-
dc.contributor.authorTam, PKH-
dc.date.accessioned2021-01-11T13:59:07Z-
dc.date.available2021-01-11T13:59:07Z-
dc.date.issued2020-
dc.identifier.citationJournal of Paediatrics and Child Health, 2020, v. 56 n. 11, p. 1774-1778-
dc.identifier.issn1034-4810-
dc.identifier.urihttp://hdl.handle.net/10722/295370-
dc.description.abstractAim: This study compared the outcomes of patients with biliary atresia (BA) treated according to a standardised protocol with historical patients. Methods: This is a single‐centred retrospective study of BA patients treated from 1980 to 2016. A standardised treatment protocol was established since 2008 regarding peri‐operative management. The outcomes being compared between the two groups (Groups I and II = before and after 2008, respectively) were jaundice clearance (JC), incidence of recurrent cholangitis, hospital admission and native liver survival (NLS). Results: A total of 128 patients were included (Group I = 100, Group II = 28). The overall median follow‐up period was 15.3 years (I vs. II = 20.6 years vs. 5.1 years, respectively). There was no significant difference in the JC at the sixth month between the two groups (I vs. II = 60.0 vs. 82.1%, respectively, P = 0.07). The incidence of recurrent cholangitis was similar between the two groups (I vs. II = 39 vs. 35.7%, respectively, P = 0.45), but the median hospital admission episode per patient was non‐significantly higher in Group I (I vs. II = 4.2 vs. 2.7, respectively, P = 0.08). There was an improvement in the 1‐year NLS rate in Group II (I vs. II = 69.0 vs. 85.7%, respectively, P = 0.05). Conclusions: The introduction of a standardised management protocol has improved the short‐term outcome of BA patients, with a better 1‐year NLS observed.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1754-
dc.relation.ispartofJournal of Paediatrics and Child Health-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbiliary atresia-
dc.subjectcholangitis-
dc.subjectKasai operation-
dc.subjectliver transplant-
dc.titleStandard management protocol to improve the short‐term outcome of biliary atresia-
dc.typeArticle-
dc.identifier.emailChung, PHY: chungphy@hku.hk-
dc.identifier.emailWong, KKY: kkywong@hku.hk-
dc.identifier.emailTam, PKH: paultam@hku.hk-
dc.identifier.authorityChung, PHY=rp02002-
dc.identifier.authorityWong, KKY=rp01392-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jpc.14698-
dc.identifier.pmid33197970-
dc.identifier.scopuseid_2-s2.0-85096047357-
dc.identifier.hkuros320793-
dc.identifier.volume56-
dc.identifier.issue11-
dc.identifier.spage1774-
dc.identifier.epage1778-
dc.identifier.isiWOS:000589510200018-
dc.publisher.placeAustralia-

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