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Article: Role of Nurr1 in Carcinogenesis and Tumor Immunology: A State of the Art Review

TitleRole of Nurr1 in Carcinogenesis and Tumor Immunology: A State of the Art Review
Authors
KeywordsNurr1
NR4A2
carcinogenesis
cell signaling
immunology
Issue Date2020
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cancers/
Citation
Cancers, 2020, v. 12 n. 10, p. article no. 3044 How to Cite?
AbstractNuclear receptor related-1 protein (Nurr1), coded by an early response gene, is involved in multiple cellular and physiological functions, including proliferation, survival, and self-renewal. Dysregulation of Nurr1 has been frequently observed in many cancers and is attributed to multiple transcriptional and post-transcriptional mechanisms. Besides, Nurr1 exhibits extensive crosstalk with many oncogenic and tumor suppressor molecules, which contribute to its potential pro-malignant behaviors. Furthermore, Nurr1 is a key player in attenuating antitumor immune responses. It not only potentiates immunosuppressive functions of regulatory T cells but also dampens the activity of cytotoxic T cells. The selective accessibility of chromatin by Nurr1 in T cells is closely associated with cell exhaustion and poor efficacy of cancer immunotherapy. In this review, we summarize the reported findings of Nurr1 in different malignancies, the mechanisms that regulate Nurr1 expression, and the downstream signaling pathways that Nurr1 employs to promote a wide range of malignant phenotypes. We also give an overview of the association between Nurr1 and antitumor immunity and discuss the inhibition of Nurr1 as a potential immunotherapeutic strategy.
Persistent Identifierhttp://hdl.handle.net/10722/294181
ISSN
2018 Impact Factor: 6.162
2020 SCImago Journal Rankings: 1.818
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWAN, PKT-
dc.contributor.authorSiu, MKY-
dc.contributor.authorLeung, THY-
dc.contributor.authorMO, XT-
dc.contributor.authorChan, KKL-
dc.contributor.authorNgan, HYS-
dc.date.accessioned2020-11-23T08:27:32Z-
dc.date.available2020-11-23T08:27:32Z-
dc.date.issued2020-
dc.identifier.citationCancers, 2020, v. 12 n. 10, p. article no. 3044-
dc.identifier.issn2072-6694-
dc.identifier.urihttp://hdl.handle.net/10722/294181-
dc.description.abstractNuclear receptor related-1 protein (Nurr1), coded by an early response gene, is involved in multiple cellular and physiological functions, including proliferation, survival, and self-renewal. Dysregulation of Nurr1 has been frequently observed in many cancers and is attributed to multiple transcriptional and post-transcriptional mechanisms. Besides, Nurr1 exhibits extensive crosstalk with many oncogenic and tumor suppressor molecules, which contribute to its potential pro-malignant behaviors. Furthermore, Nurr1 is a key player in attenuating antitumor immune responses. It not only potentiates immunosuppressive functions of regulatory T cells but also dampens the activity of cytotoxic T cells. The selective accessibility of chromatin by Nurr1 in T cells is closely associated with cell exhaustion and poor efficacy of cancer immunotherapy. In this review, we summarize the reported findings of Nurr1 in different malignancies, the mechanisms that regulate Nurr1 expression, and the downstream signaling pathways that Nurr1 employs to promote a wide range of malignant phenotypes. We also give an overview of the association between Nurr1 and antitumor immunity and discuss the inhibition of Nurr1 as a potential immunotherapeutic strategy.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cancers/-
dc.relation.ispartofCancers-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectNurr1-
dc.subjectNR4A2-
dc.subjectcarcinogenesis-
dc.subjectcell signaling-
dc.subjectimmunology-
dc.titleRole of Nurr1 in Carcinogenesis and Tumor Immunology: A State of the Art Review-
dc.typeArticle-
dc.identifier.emailSiu, MKY: mkysiu@hku.hk-
dc.identifier.emailChan, KKL: kklchan@hkucc.hku.hk-
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hk-
dc.identifier.authoritySiu, MKY=rp00275-
dc.identifier.authorityChan, KKL=rp00499-
dc.identifier.authorityNgan, HYS=rp00346-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/cancers12103044-
dc.identifier.pmid33086676-
dc.identifier.pmcidPMC7590204-
dc.identifier.scopuseid_2-s2.0-85093703010-
dc.identifier.hkuros319183-
dc.identifier.volume12-
dc.identifier.issue10-
dc.identifier.spagearticle no. 3044-
dc.identifier.epagearticle no. 3044-
dc.identifier.isiWOS:000584052400001-
dc.publisher.placeSwitzerland-
dc.identifier.issnl2072-6694-

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