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Article: Left and Right Atrial Function and Remodeling in Beta-Thalassaemia Major

TitleLeft and Right Atrial Function and Remodeling in Beta-Thalassaemia Major
Authors
KeywordsBeta-thalassemia major
Atrial function
Strain
Issue Date2019
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246
Citation
Pediatric Cardiology, 2019, v. 40, p. 1001-1008 How to Cite?
AbstractThis study aimed to assess left (LA) and right atrial (RA) function in patients with beta-thalassaemia major. Thirty-eight patients (19 males) aged 34.5 ± 10.7 years and 43 (18 males) controls aged 30.3 ± 12.6 years (p = 0.12) were studied. The maximum RA and LA areas were measured using two-dimensional planimetry, while atrial and ventricular strain and strain rates were quantified using speckle-tracking echocardiography. Compared with controls, patients had significantly reduced LA and RA peak positive strain and total strain, and LA strain rate during ventricular systole and at atrial contraction (all p < 0.05). The LA and RA strain parameters were significantly associated (all p < 0.05). The maximum LA (10.2 ± 1.6 cm2/m2 vs. 8.6 ± 1.3 cm2/m2, p < 0.001) and RA (9.2 ± 1.2 cm2/m2 vs. 7.5 ± 1.3 cm2/m2, p < 0.001) areas were significantly greater in patients than controls. The LV and RV strain and early strain rates were similar between patients and controls (all p > 0.05). Four patients with significant myocardial iron overload had larger LA area (p < 0.001) than those without. Functional and structural remodeling of both the right and left atria occurs in patients with beta-thalassaemia major, even in the absence of ventricular diastolic dysfunction.
Persistent Identifierhttp://hdl.handle.net/10722/290598
ISSN
2019 Impact Factor: 1.564
2015 SCImago Journal Rankings: 0.732

 

DC FieldValueLanguage
dc.contributor.authorCheung, YF-
dc.contributor.authorSo, EKF-
dc.contributor.authorHwang, GYY-
dc.contributor.authorChan, GCF-
dc.contributor.authorHa, SY-
dc.date.accessioned2020-11-02T05:44:30Z-
dc.date.available2020-11-02T05:44:30Z-
dc.date.issued2019-
dc.identifier.citationPediatric Cardiology, 2019, v. 40, p. 1001-1008-
dc.identifier.issn0172-0643-
dc.identifier.urihttp://hdl.handle.net/10722/290598-
dc.description.abstractThis study aimed to assess left (LA) and right atrial (RA) function in patients with beta-thalassaemia major. Thirty-eight patients (19 males) aged 34.5 ± 10.7 years and 43 (18 males) controls aged 30.3 ± 12.6 years (p = 0.12) were studied. The maximum RA and LA areas were measured using two-dimensional planimetry, while atrial and ventricular strain and strain rates were quantified using speckle-tracking echocardiography. Compared with controls, patients had significantly reduced LA and RA peak positive strain and total strain, and LA strain rate during ventricular systole and at atrial contraction (all p < 0.05). The LA and RA strain parameters were significantly associated (all p < 0.05). The maximum LA (10.2 ± 1.6 cm2/m2 vs. 8.6 ± 1.3 cm2/m2, p < 0.001) and RA (9.2 ± 1.2 cm2/m2 vs. 7.5 ± 1.3 cm2/m2, p < 0.001) areas were significantly greater in patients than controls. The LV and RV strain and early strain rates were similar between patients and controls (all p > 0.05). Four patients with significant myocardial iron overload had larger LA area (p < 0.001) than those without. Functional and structural remodeling of both the right and left atria occurs in patients with beta-thalassaemia major, even in the absence of ventricular diastolic dysfunction.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00246-
dc.relation.ispartofPediatric Cardiology-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectBeta-thalassemia major-
dc.subjectAtrial function-
dc.subjectStrain-
dc.titleLeft and Right Atrial Function and Remodeling in Beta-Thalassaemia Major-
dc.typeArticle-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.emailSo, EKF: edwinaso@hku.hk-
dc.identifier.emailHwang, GYY: yyhwang@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailHa, SY: syha@hku.hk-
dc.identifier.authorityCheung, YF=rp00382-
dc.identifier.authorityChan, GCF=rp00431-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00246-019-02105-3-
dc.identifier.pmid30972436-
dc.identifier.scopuseid_2-s2.0-85066917791-
dc.identifier.hkuros317778-
dc.identifier.volume40-
dc.identifier.spage1001-
dc.identifier.epage1008-
dc.publisher.placeUnited States-
dc.identifier.issnl0172-0643-

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