Radiotherapy in the management of glottic squamous cell carcinoma

Abstract

Introduction: Our purpose is to review the role radiotherapy (RT) in the treatment of glottic squamous cell carcinoma (SCC).

Methods: A concise review of the pertinent literature.

Results: RT cure rates are Tis‐ T1N0, 90% to 95%; T2N0, 70% to 80%; low‐volume T3‐T4a, 65% to 70%. Concomitant cisplatin is given for T3‐T4a SCCs. Severe complications occur in 1% to 2% for Tis‐T2N0 and 10% for T3‐T4a SCCs. Patients with high‐volume T3‐T4 SCCs undergo total laryngectomy, neck dissection, and postoperative RT. Those with positive margins and/or extranodal extension receive concomitant cisplatin. The likelihood of local‐regional control at 5 years is 85% to 90%. Severe complications occur in 5% to 10%.

Conclusions: RT is a good treatment option for patients with Tis‐T2N0 and low‐volume T3‐T4a glottic SCCs. Patients with higher volume T3‐T4 cancers are best treated with surgery and postoperative RT.