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Article: When compared to plasma‐based detection, osimertinib‐treated non‐small cell lung cancer (NSCLC) with tissue rebiopsy‐confirmed acquired T790M mutation is associated with better survival

TitleWhen compared to plasma‐based detection, osimertinib‐treated non‐small cell lung cancer (NSCLC) with tissue rebiopsy‐confirmed acquired T790M mutation is associated with better survival
Authors
KeywordsEGFR
lung cancer
osimertinib
Issue Date2019
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1743-7563
Citation
Asia-Pacific Journal of Clinical Oncology, 2019, Epub 2019-12-04 How to Cite?
AbstractBackground Osimertinib has been approved by the Food and Drug Administration (FDA) of the United States (US) for the treatment of progressive non‐small cell lung cancer (NSCLC) that has acquired T790M mutation during treatment with first‐line epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKI). We compared the progression‐free survival (PFS) of patients whose T790M mutation was identified by tissue rebiopsy with those by plasma‐based biopsy. Methods This is a retrospective single‐center cohort study conducted in Queen Mary Hospital, Hong Kong S.A.R. that included 118 Chinese patients with advanced NSCLC who had disease progression after treatment with a first‐line EGFR tyrosine kinase inhibitor and received osimertinib upon detection of T790M mutation, either by tissue rebiopsy or plasma‐based biopsy (by identification of circulating tumor DNA in the peripheral circulation). The primary endpoint is PFS. Results Patients with T790M mutation detected by tissue rebiopsy (n = 22) had significantly better PFS than those by plasma‐based biopsy (n = 96) (median PFS: 415 vs 224 days, P = .018) Hazard ratio for PFS, in favor of the tissue rebiopsy group, was 0.496 (95% confidence interval [CI]: 0.277‐0.889). Conclusions For patients who have NSCLC that progressed after first‐line EGFR‐TKI, rebiopsy by peripheral blood liquid biopsy and tissue rebiopsy for T790M mutation may have prognostic implication in terms of differences in PFS.
Persistent Identifierhttp://hdl.handle.net/10722/286242
ISSN
2020 Impact Factor: 2.601
2020 SCImago Journal Rankings: 0.730
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, WC-
dc.contributor.authorHo, JCM-
dc.contributor.authorLam, DCL-
dc.contributor.authorLui, MMS-
dc.contributor.authorIp, MSM-
dc.contributor.authorTam, TCC-
dc.date.accessioned2020-08-31T07:01:10Z-
dc.date.available2020-08-31T07:01:10Z-
dc.date.issued2019-
dc.identifier.citationAsia-Pacific Journal of Clinical Oncology, 2019, Epub 2019-12-04-
dc.identifier.issn1743-7555-
dc.identifier.urihttp://hdl.handle.net/10722/286242-
dc.description.abstractBackground Osimertinib has been approved by the Food and Drug Administration (FDA) of the United States (US) for the treatment of progressive non‐small cell lung cancer (NSCLC) that has acquired T790M mutation during treatment with first‐line epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKI). We compared the progression‐free survival (PFS) of patients whose T790M mutation was identified by tissue rebiopsy with those by plasma‐based biopsy. Methods This is a retrospective single‐center cohort study conducted in Queen Mary Hospital, Hong Kong S.A.R. that included 118 Chinese patients with advanced NSCLC who had disease progression after treatment with a first‐line EGFR tyrosine kinase inhibitor and received osimertinib upon detection of T790M mutation, either by tissue rebiopsy or plasma‐based biopsy (by identification of circulating tumor DNA in the peripheral circulation). The primary endpoint is PFS. Results Patients with T790M mutation detected by tissue rebiopsy (n = 22) had significantly better PFS than those by plasma‐based biopsy (n = 96) (median PFS: 415 vs 224 days, P = .018) Hazard ratio for PFS, in favor of the tissue rebiopsy group, was 0.496 (95% confidence interval [CI]: 0.277‐0.889). Conclusions For patients who have NSCLC that progressed after first‐line EGFR‐TKI, rebiopsy by peripheral blood liquid biopsy and tissue rebiopsy for T790M mutation may have prognostic implication in terms of differences in PFS.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1743-7563-
dc.relation.ispartofAsia-Pacific Journal of Clinical Oncology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectEGFR-
dc.subjectlung cancer-
dc.subjectosimertinib-
dc.titleWhen compared to plasma‐based detection, osimertinib‐treated non‐small cell lung cancer (NSCLC) with tissue rebiopsy‐confirmed acquired T790M mutation is associated with better survival-
dc.typeArticle-
dc.identifier.emailHo, JCM: jhocm@hku.hk-
dc.identifier.emailLam, DCL: dcllam@hku.hk-
dc.identifier.emailLui, MMS: drmslui@hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.emailTam, TCC: tamcct@hku.hk-
dc.identifier.authorityHo, JCM=rp00258-
dc.identifier.authorityLam, DCL=rp01345-
dc.identifier.authorityIp, MSM=rp00347-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/ajco.13287-
dc.identifier.pmid31802642-
dc.identifier.scopuseid_2-s2.0-85076284205-
dc.identifier.hkuros313371-
dc.identifier.volumeEpub 2019-12-04-
dc.identifier.isiWOS:000500536900001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1743-7555-

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