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- Publisher Website: 10.1093/ehjci/jeaa079
- Scopus: eid_2-s2.0-85096518238
- PMID: 32372092
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Article: Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus
Title | Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus |
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Authors | |
Keywords | Type 2 diabetes diastolic function sex outcome |
Issue Date | 2020 |
Publisher | Oxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org |
Citation | European Heart Journal - Cardiovascular Imaging, 2020, Epub 2020-05-05 How to Cite? |
Abstract | Aims:
Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodelling, and diastolic dysfunction in patients with type 2 diabetes (T2DM). The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodelling, and diastolic dysfunction in patients with T2DM. Further, the prognostic value of diastolic function in women and men was also evaluated.
Methods and results:
A total of 350 patients with T2DM (mean age 61 ± 11 years; women, 48.3%) was recruited. Detailed echocardiography was performed at baseline and after 25 months. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization, or myocardial infarction. Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 21 patients developed MACE (5 cardiovascular death, 9 hospitalization for heart failure, and 7 myocardial infarction) during a median follow-up of 56 months. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women [hazard ratio = 6.30; 95% confidence interval (CI) = 1.06–37.54; P < 0.05] but not men (hazard ratio = 2.29, 95% CI = 0.67–7.89; P = 0.19).
Conclusion:
LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men. |
Persistent Identifier | http://hdl.handle.net/10722/284470 |
ISSN | 2023 Impact Factor: 6.7 2023 SCImago Journal Rankings: 3.011 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | WU, MZ | - |
dc.contributor.author | CHEN, Y | - |
dc.contributor.author | YU, YJ | - |
dc.contributor.author | ZHEN, Z | - |
dc.contributor.author | Liu, YX | - |
dc.contributor.author | Zou, Y | - |
dc.contributor.author | Ho, LM | - |
dc.contributor.author | Lin, QS | - |
dc.contributor.author | Ng, MY | - |
dc.contributor.author | Lam, KSL | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Yiu, KH | - |
dc.date.accessioned | 2020-08-07T08:58:04Z | - |
dc.date.available | 2020-08-07T08:58:04Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | European Heart Journal - Cardiovascular Imaging, 2020, Epub 2020-05-05 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284470 | - |
dc.description.abstract | Aims: Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodelling, and diastolic dysfunction in patients with type 2 diabetes (T2DM). The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodelling, and diastolic dysfunction in patients with T2DM. Further, the prognostic value of diastolic function in women and men was also evaluated. Methods and results: A total of 350 patients with T2DM (mean age 61 ± 11 years; women, 48.3%) was recruited. Detailed echocardiography was performed at baseline and after 25 months. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization, or myocardial infarction. Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 21 patients developed MACE (5 cardiovascular death, 9 hospitalization for heart failure, and 7 myocardial infarction) during a median follow-up of 56 months. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women [hazard ratio = 6.30; 95% confidence interval (CI) = 1.06–37.54; P < 0.05] but not men (hazard ratio = 2.29, 95% CI = 0.67–7.89; P = 0.19). Conclusion: LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org | - |
dc.relation.ispartof | European Heart Journal - Cardiovascular Imaging | - |
dc.rights | Pre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. | - |
dc.subject | Type 2 diabetes | - |
dc.subject | diastolic function | - |
dc.subject | sex | - |
dc.subject | outcome | - |
dc.title | Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus | - |
dc.type | Article | - |
dc.identifier.email | Ho, LM: lmho@hku.hk | - |
dc.identifier.email | Ng, MY: myng2@hku.hk | - |
dc.identifier.email | Lam, KSL: ksllam@hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.authority | Ho, LM=rp00360 | - |
dc.identifier.authority | Ng, MY=rp01976 | - |
dc.identifier.authority | Lam, KSL=rp00343 | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/ehjci/jeaa079 | - |
dc.identifier.pmid | 32372092 | - |
dc.identifier.scopus | eid_2-s2.0-85096518238 | - |
dc.identifier.hkuros | 311668 | - |
dc.identifier.volume | Epub 2020-05-05 | - |
dc.identifier.isi | WOS:000684075600027 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2047-2404 | - |