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Article: Functional implications of cathelicidin antimicrobial protein in breast cancer and tumor-associated macrophage microenvironment

TitleFunctional implications of cathelicidin antimicrobial protein in breast cancer and tumor-associated macrophage microenvironment
Authors
Keywordsbreast cancer
cathelicidin antimicrobia
tumor associated macrophage
tumor microenvironment
Issue Date2020
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/biomolecules
Citation
Biomolecules, 2020, v. 10 n. 5, p. article no. 688 How to Cite?
AbstractIt is well-established that tumor-associated macrophages (TAMs) play an important role in breast cancer development. Accumulating evidence suggested that human cathelicidin antimicrobial protein (CAMP), which is mainly expressed in host defense cells such as macrophages, is crucial not only in combating microorganisms but also promoting tumor growth. Here we report the interaction of CAMP with TAMs in breast cancer. CAMP expression was upregulated in cancer tissues and in the circulation of breast cancer patients. Surgical removal of tumor decreased CAMP peptide serum level. Knockdown of CAMP decreased cell proliferation and migration/invasion ability in breast cancer cells. CAMP expression was altered during macrophage M1/M2 polarization and was expressed predominantly in M2 phenotype. In addition, breast cancer cells co-cultured with macrophages upregulated CAMP expression and also increased cancer cell viability. Xenograft tumors reduced significantly upon CAMP receptor antagonist treatment. Our data implicated that CAMP confers an oncogenic role in breast cancer and plays an important role in the tumor microenvironment between TAMs and breast cancer cells, and blocking the interaction between them would provide a novel therapeutic option for this malignant disease.
Persistent Identifierhttp://hdl.handle.net/10722/282534
ISSN
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 1.179
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, J-
dc.contributor.authorShin, VY-
dc.contributor.authorHO, JC-W-
dc.contributor.authorSiu, M-T-
dc.contributor.authorCheuk, IW-Y-
dc.contributor.authorKwong, A-
dc.date.accessioned2020-05-15T05:29:22Z-
dc.date.available2020-05-15T05:29:22Z-
dc.date.issued2020-
dc.identifier.citationBiomolecules, 2020, v. 10 n. 5, p. article no. 688-
dc.identifier.issn2218-273X-
dc.identifier.urihttp://hdl.handle.net/10722/282534-
dc.description.abstractIt is well-established that tumor-associated macrophages (TAMs) play an important role in breast cancer development. Accumulating evidence suggested that human cathelicidin antimicrobial protein (CAMP), which is mainly expressed in host defense cells such as macrophages, is crucial not only in combating microorganisms but also promoting tumor growth. Here we report the interaction of CAMP with TAMs in breast cancer. CAMP expression was upregulated in cancer tissues and in the circulation of breast cancer patients. Surgical removal of tumor decreased CAMP peptide serum level. Knockdown of CAMP decreased cell proliferation and migration/invasion ability in breast cancer cells. CAMP expression was altered during macrophage M1/M2 polarization and was expressed predominantly in M2 phenotype. In addition, breast cancer cells co-cultured with macrophages upregulated CAMP expression and also increased cancer cell viability. Xenograft tumors reduced significantly upon CAMP receptor antagonist treatment. Our data implicated that CAMP confers an oncogenic role in breast cancer and plays an important role in the tumor microenvironment between TAMs and breast cancer cells, and blocking the interaction between them would provide a novel therapeutic option for this malignant disease.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/biomolecules-
dc.relation.ispartofBiomolecules-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbreast cancer-
dc.subjectcathelicidin antimicrobia-
dc.subjecttumor associated macrophage-
dc.subjecttumor microenvironment-
dc.titleFunctional implications of cathelicidin antimicrobial protein in breast cancer and tumor-associated macrophage microenvironment-
dc.typeArticle-
dc.identifier.emailChen, J: gary0526@hku.hk-
dc.identifier.emailShin, VY: vyshin@hku.hk-
dc.identifier.emailSiu, M-T: jensiu@hku.hk-
dc.identifier.emailCheuk, IW-Y: isacheuk@hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityShin, VY=rp02000-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/biom10050688-
dc.identifier.pmid32365569-
dc.identifier.scopuseid_2-s2.0-85084276511-
dc.identifier.hkuros309907-
dc.identifier.volume10-
dc.identifier.issue5-
dc.identifier.spagearticle no. 688-
dc.identifier.epagearticle no. 688-
dc.identifier.isiWOS:000545013700025-
dc.publisher.placeSwitzerland-
dc.identifier.issnl2218-273X-

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