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Conference Paper: Predictors of long-term outcomes of first episode schizophrenia-spectrum disorders
Title | Predictors of long-term outcomes of first episode schizophrenia-spectrum disorders |
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Authors | |
Issue Date | 2018 |
Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893 |
Citation | The 11th International Conference on Early Intervention in Mental Health: Prevention and Early Intervention: Broadening the Scope (IEPA 11), Boston, USA, 7-10 October 2018. In Early Intervention in Psychiatry, 2018, v. 12 n. Suppl 1, p. 47 How to Cite? The 11th International Conference on Early Intervention in Mental Health: Prevention and Early Intervention: Broadening the Scope (IEPA 11), Boston, USA, 7-10 October 2018. In Early Intervention in Psychiatry, 2018, , v. 12 n. Suppl 1, p. 47 How to Cite? |
Abstract | Despite of the improvement in intervention, long term outcomes of patients with schizophrenia has not improved much. Early clinical characteristics has been suggested to predict the long-term outcomes. The current study is to look at predictors of early clinical characteristics including relapse and planned discontinuation of antipsychotic medications to long-term outcomes including suicide, treatment resistance and recovery in patients with schizophrenia-spectrum disorders. Apart from basic demographics, information of baseline clinical condition including positive and negative symptoms, duration of untreated psychosis (DUP), suicidal attempts during DUP; clinical characteristics during the first three years including number of relapse, number hospitalization, compliance, suicidal attempts, planned discontinuation of antipsychotic medications were obtained from clinical record review. The review was conducted at monthly basis with standardized entry form with operational definitions. Suicide information was obtained at 12-year follow up of 1400 patients. Results suggested number of relapse, premorbid functional impairment and compliance predicted suicide in year 4 to 12 (p=0.002), whereas suicide attempts in DUP and first three years predicted suicide in year 1-3(p=0.004). Among the 1400 patients, 165 patients were considered treatment resistant by 12-year follow up. Use case-control study approach with control patients who were randomly identified among the 1400 patients matched with diagnosis of patients with treatment resistance. A total of 290 patient control was identified. Results suggested patients with treatment resistant had younger age of onset, lower years of education, poorer premorbid adjustment, more number of hospitalization and relapse during the initial three years of treatment than the patient control. |
Description | Symposium Session 27 - Talk 3 |
Persistent Identifier | http://hdl.handle.net/10722/278744 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.976 |
DC Field | Value | Language |
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dc.contributor.author | Chan, KW | - |
dc.contributor.author | Hui, CLM | - |
dc.contributor.author | Lee, HME | - |
dc.contributor.author | Chang, WC | - |
dc.contributor.author | Chen, EYH | - |
dc.date.accessioned | 2019-10-21T02:13:15Z | - |
dc.date.available | 2019-10-21T02:13:15Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | The 11th International Conference on Early Intervention in Mental Health: Prevention and Early Intervention: Broadening the Scope (IEPA 11), Boston, USA, 7-10 October 2018. In Early Intervention in Psychiatry, 2018, v. 12 n. Suppl 1, p. 47 | - |
dc.identifier.citation | The 11th International Conference on Early Intervention in Mental Health: Prevention and Early Intervention: Broadening the Scope (IEPA 11), Boston, USA, 7-10 October 2018. In Early Intervention in Psychiatry, 2018, , v. 12 n. Suppl 1, p. 47 | - |
dc.identifier.issn | 1751-7885 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278744 | - |
dc.description | Symposium Session 27 - Talk 3 | - |
dc.description.abstract | Despite of the improvement in intervention, long term outcomes of patients with schizophrenia has not improved much. Early clinical characteristics has been suggested to predict the long-term outcomes. The current study is to look at predictors of early clinical characteristics including relapse and planned discontinuation of antipsychotic medications to long-term outcomes including suicide, treatment resistance and recovery in patients with schizophrenia-spectrum disorders. Apart from basic demographics, information of baseline clinical condition including positive and negative symptoms, duration of untreated psychosis (DUP), suicidal attempts during DUP; clinical characteristics during the first three years including number of relapse, number hospitalization, compliance, suicidal attempts, planned discontinuation of antipsychotic medications were obtained from clinical record review. The review was conducted at monthly basis with standardized entry form with operational definitions. Suicide information was obtained at 12-year follow up of 1400 patients. Results suggested number of relapse, premorbid functional impairment and compliance predicted suicide in year 4 to 12 (p=0.002), whereas suicide attempts in DUP and first three years predicted suicide in year 1-3(p=0.004). Among the 1400 patients, 165 patients were considered treatment resistant by 12-year follow up. Use case-control study approach with control patients who were randomly identified among the 1400 patients matched with diagnosis of patients with treatment resistance. A total of 290 patient control was identified. Results suggested patients with treatment resistant had younger age of onset, lower years of education, poorer premorbid adjustment, more number of hospitalization and relapse during the initial three years of treatment than the patient control. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893 | - |
dc.relation.ispartof | Early Intervention in Psychiatry | - |
dc.relation.ispartof | The IEPA 11th International Conference on Early Intervention in Mental Health, 2018 | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.title | Predictors of long-term outcomes of first episode schizophrenia-spectrum disorders | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, KW: kwsherry@hku.hk | - |
dc.identifier.email | Hui, CLM: christyh@hku.hk | - |
dc.identifier.email | Lee, HME: edwinlhm@hku.hk | - |
dc.identifier.email | Chang, WC: changwc@hku.hk | - |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | - |
dc.identifier.authority | Chan, KW=rp00539 | - |
dc.identifier.authority | Hui, CLM=rp01993 | - |
dc.identifier.authority | Lee, HME=rp01575 | - |
dc.identifier.authority | Chang, WC=rp01465 | - |
dc.identifier.authority | Chen, EYH=rp00392 | - |
dc.identifier.hkuros | 307295 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | Suppl 1 | - |
dc.identifier.spage | 47 | - |
dc.identifier.epage | 47 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1751-7885 | - |