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Conference Paper: Central and Peripheral Arterial Stiffness in Patients After Surgical Repair of Tetralogy of Fallot: Implications for Aortic Root Dilation

TitleCentral and Peripheral Arterial Stiffness in Patients After Surgical Repair of Tetralogy of Fallot: Implications for Aortic Root Dilation
Authors
Issue Date2006
PublisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org
Citation
American Heart Association Scientific Sessions 2006, Chicago, Illinois, USA, 12-15 November 2006. Abstracts in Circulation, 2006, v. 114 n. Suppl. 18, p. 780, Abstract 3653 How to Cite?
AbstractBackground: Intrinsic histological abnormalities of the aorta and progressive aortic root dilation after surgical repair are documented in TOF patients. We sought to test the hypotheses that: 1.preferential stiffening of the central over the peripheral conduit arteries occurs in patients after surgical repair of tetralogy of Fallot (TOF); and 2.central arterial stiffening is related to aortic root dilation. Methods: The heart-femoral pulse wave velocity (PWV), femoral-ankle PWV, carotid augmentation index, and body surface area-adjusted aortic sinotubular dimension, were determined in 31 children after TOF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension. Results: When compared with controls, patients had significant greater heart-femoral PWV (666± 151 cm/s vs 587± 81 cm/s, p=0.021) and carotid augmentation index (−14.1± 17.0 % vs −25.2± 14.6 %, p=0.016), whereas the right (p=0.42) and left (p=0.25) femoral-ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7± 1.5 vs 1.1± 1.4, p<0.001). Univariate analysis showed that sinotubular junction z score correlated positively with diastolic blood pressure (r=0.26, p=0.04), heart-femoral PWV (r=0.43, p=0.001), and carotid augmentation index (r=0.46, p=0.001). Multiple linear regression identified patient group (β =0.72, p<0.001) and heart-femoral PWV (β =0.26, p=0.007) (model R2=0.70) as significant determinants of sinotubular junction z score. Conclusions: Aortic stiffening occurs in patients after repair of TOF, which may contribute to progressive dilation of the aortic root in the long-term.
DescriptionClinical Science - Session Pediatric and Congenital - Abstract 3653
Persistent Identifierhttp://hdl.handle.net/10722/276439
ISSN
2019 Impact Factor: 23.603
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorCheung, YF-
dc.contributor.authorOu, X-
dc.contributor.authorWong, SJ-
dc.date.accessioned2019-09-10T09:30:51Z-
dc.date.available2019-09-10T09:30:51Z-
dc.date.issued2006-
dc.identifier.citationAmerican Heart Association Scientific Sessions 2006, Chicago, Illinois, USA, 12-15 November 2006. Abstracts in Circulation, 2006, v. 114 n. Suppl. 18, p. 780, Abstract 3653-
dc.identifier.issn0009-7322-
dc.identifier.urihttp://hdl.handle.net/10722/276439-
dc.descriptionClinical Science - Session Pediatric and Congenital - Abstract 3653-
dc.description.abstractBackground: Intrinsic histological abnormalities of the aorta and progressive aortic root dilation after surgical repair are documented in TOF patients. We sought to test the hypotheses that: 1.preferential stiffening of the central over the peripheral conduit arteries occurs in patients after surgical repair of tetralogy of Fallot (TOF); and 2.central arterial stiffening is related to aortic root dilation. Methods: The heart-femoral pulse wave velocity (PWV), femoral-ankle PWV, carotid augmentation index, and body surface area-adjusted aortic sinotubular dimension, were determined in 31 children after TOF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension. Results: When compared with controls, patients had significant greater heart-femoral PWV (666± 151 cm/s vs 587± 81 cm/s, p=0.021) and carotid augmentation index (−14.1± 17.0 % vs −25.2± 14.6 %, p=0.016), whereas the right (p=0.42) and left (p=0.25) femoral-ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7± 1.5 vs 1.1± 1.4, p<0.001). Univariate analysis showed that sinotubular junction z score correlated positively with diastolic blood pressure (r=0.26, p=0.04), heart-femoral PWV (r=0.43, p=0.001), and carotid augmentation index (r=0.46, p=0.001). Multiple linear regression identified patient group (β =0.72, p<0.001) and heart-femoral PWV (β =0.26, p=0.007) (model R2=0.70) as significant determinants of sinotubular junction z score. Conclusions: Aortic stiffening occurs in patients after repair of TOF, which may contribute to progressive dilation of the aortic root in the long-term.-
dc.languageeng-
dc.publisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org-
dc.relation.ispartofCirculation-
dc.relation.ispartofAmerican Heart Association, Scientific Sessions 2006-
dc.titleCentral and Peripheral Arterial Stiffness in Patients After Surgical Repair of Tetralogy of Fallot: Implications for Aortic Root Dilation-
dc.typeConference_Paper-
dc.identifier.emailCheung, YF: xfcheung@hkucc.hku.hk-
dc.identifier.emailWong, SJ: sjwong@HKUCC.hku.hk-
dc.identifier.authorityCheung, YF=rp00382-
dc.identifier.hkuros125087-
dc.identifier.volume114-
dc.identifier.issueSuppl. 18-
dc.identifier.spage780, Abstract 3653-
dc.identifier.epage780, Abstract 3653-
dc.publisher.placeUnited States-

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