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Article: First reported case of afatinib-associated toxic megacolon

TitleFirst reported case of afatinib-associated toxic megacolon
Authors
KeywordsAfatinib
Lung cancer
Toxic megacolon
Issue Date2018
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2051-3380
Citation
Respirology Case Reports, 2018, v. 6 n. 7, article no. e00360 How to Cite?
AbstractWe report the first case of toxic megacolon associated with afatinib use, which is a potentially fatal complication, with risks of colonic perforation. In this case, the condition improved on stopping afatnib. Clinicians need to be alert of this rare but fatal adverse effect and to avoid anti‐diarrhoeal agents, which can worsen toxic megacolon. Anti‐diarrhoeal agents are routinely given if diarrhoea occurs on afatinib. These should be stopped and avoided if toxic megacolon occurs.
Persistent Identifierhttp://hdl.handle.net/10722/275130
ISSN
2020 SCImago Journal Rankings: 0.304
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, WC-
dc.contributor.authorTam, TCC-
dc.contributor.authorLam, DCL-
dc.date.accessioned2019-09-10T02:36:05Z-
dc.date.available2019-09-10T02:36:05Z-
dc.date.issued2018-
dc.identifier.citationRespirology Case Reports, 2018, v. 6 n. 7, article no. e00360-
dc.identifier.issn2051-3380-
dc.identifier.urihttp://hdl.handle.net/10722/275130-
dc.description.abstractWe report the first case of toxic megacolon associated with afatinib use, which is a potentially fatal complication, with risks of colonic perforation. In this case, the condition improved on stopping afatnib. Clinicians need to be alert of this rare but fatal adverse effect and to avoid anti‐diarrhoeal agents, which can worsen toxic megacolon. Anti‐diarrhoeal agents are routinely given if diarrhoea occurs on afatinib. These should be stopped and avoided if toxic megacolon occurs.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2051-3380-
dc.relation.ispartofRespirology Case Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAfatinib-
dc.subjectLung cancer-
dc.subjectToxic megacolon-
dc.titleFirst reported case of afatinib-associated toxic megacolon-
dc.typeArticle-
dc.identifier.emailLam, DCL: dcllam@hku.hk-
dc.identifier.authorityLam, DCL=rp01345-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/rcr2.360-
dc.identifier.pmid30186606-
dc.identifier.pmcidPMC6117793-
dc.identifier.hkuros304729-
dc.identifier.volume6-
dc.identifier.issue7-
dc.identifier.spagearticle no. e00360-
dc.identifier.epagearticle no. e00360-
dc.identifier.isiWOS:000444473000014-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2051-3380-

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