File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.bmcl.2011.11.109
- Scopus: eid_2-s2.0-84855675976
- PMID: 22196120
- WOS: WOS:000299653500067
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.
Title | Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. |
---|---|
Authors | |
Keywords | Excoecariphenols A-D NS3-4A protein kinase inhibition Mangrove plant HCV RNA inhibition Huh 7.5 cells Excoecaria agallocha L. |
Issue Date | 2012 |
Citation | Bioorganic and Medicinal Chemistry Letters, 2012, v. 22, n. 2, p. 1099-1102 How to Cite? |
Abstract | Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC 50 values in a range of 3.45-9.03 μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed. © 2011 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/273510 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.508 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Yongxin | - |
dc.contributor.author | Yu, Shanjiang | - |
dc.contributor.author | Liu, Dong | - |
dc.contributor.author | Proksch, Peter | - |
dc.contributor.author | Lin, Wenhan | - |
dc.date.accessioned | 2019-08-12T09:55:48Z | - |
dc.date.available | 2019-08-12T09:55:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters, 2012, v. 22, n. 2, p. 1099-1102 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10722/273510 | - |
dc.description.abstract | Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC 50 values in a range of 3.45-9.03 μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed. © 2011 Elsevier Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Bioorganic and Medicinal Chemistry Letters | - |
dc.subject | Excoecariphenols A-D | - |
dc.subject | NS3-4A protein kinase inhibition | - |
dc.subject | Mangrove plant | - |
dc.subject | HCV RNA inhibition | - |
dc.subject | Huh 7.5 cells | - |
dc.subject | Excoecaria agallocha L. | - |
dc.title | Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bmcl.2011.11.109 | - |
dc.identifier.pmid | 22196120 | - |
dc.identifier.scopus | eid_2-s2.0-84855675976 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 1099 | - |
dc.identifier.epage | 1102 | - |
dc.identifier.eissn | 1464-3405 | - |
dc.identifier.isi | WOS:000299653500067 | - |
dc.identifier.issnl | 0960-894X | - |