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Article: A Lateral Inhibition Mechanism Explains the Dissociation between Mismatch Negativity and Behavioral Pitch Discrimination

TitleA Lateral Inhibition Mechanism Explains the Dissociation between Mismatch Negativity and Behavioral Pitch Discrimination
Authors
KeywordsMismatch negativity
Pitch perception
Lateral inhibition
Auditory discriminationTonotopy
Oddball paradigm
Issue Date2019
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2019, v. 1720, p. article no. 146308 How to Cite?
AbstractAlthough mismatch negativity (MMN), a change-specific component of auditory event-related potential, is considered to be an index of sound discrimination accuracy, the amplitude of the MMN responses elicited by pitch height deviations in musicians and tone language speakers with superior pitch discrimination is usually not enhanced compared to that elicited in individuals with inferior pitch discrimination. We hypothesized that superior pitch discrimination is accompanied by enhanced lateral inhibition, a critical neural mechanism that sharpens the tuning curves of the auditory neurons in the tonotopy. Forty Mandarin-speaking healthy adults completed an auditory EEG experiment in which MMN was elicited by pitch height deviations in both pure and harmonic tones. Their behavioral pitch discrimination was indexed by the difference limens measured using pure and harmonic tones. Behavioral pitch discrimination correlated significantly with the MMN elicited by pure tones, but not by harmonic tones; this could be due to lateral inhibition strongly influencing the MMN elicited by harmonic tones but having less effect on the MMN elicited by pure tones. As lateral inhibition is a neural mechanism for attenuating the amplitude of MMN, our results support the notion that an enhanced lateral inhibition mechanism underlies superior pitch discrimination.
Persistent Identifierhttp://hdl.handle.net/10722/273000
ISSN
2019 Impact Factor: 2.733
2015 SCImago Journal Rankings: 1.351

 

DC FieldValueLanguage
dc.contributor.authorGu, F-
dc.contributor.authorWong, L-
dc.contributor.authorHu, A-
dc.contributor.authorZhang, X-
dc.contributor.authorTong, X-
dc.date.accessioned2019-08-06T09:20:41Z-
dc.date.available2019-08-06T09:20:41Z-
dc.date.issued2019-
dc.identifier.citationBrain Research, 2019, v. 1720, p. article no. 146308-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/10722/273000-
dc.description.abstractAlthough mismatch negativity (MMN), a change-specific component of auditory event-related potential, is considered to be an index of sound discrimination accuracy, the amplitude of the MMN responses elicited by pitch height deviations in musicians and tone language speakers with superior pitch discrimination is usually not enhanced compared to that elicited in individuals with inferior pitch discrimination. We hypothesized that superior pitch discrimination is accompanied by enhanced lateral inhibition, a critical neural mechanism that sharpens the tuning curves of the auditory neurons in the tonotopy. Forty Mandarin-speaking healthy adults completed an auditory EEG experiment in which MMN was elicited by pitch height deviations in both pure and harmonic tones. Their behavioral pitch discrimination was indexed by the difference limens measured using pure and harmonic tones. Behavioral pitch discrimination correlated significantly with the MMN elicited by pure tones, but not by harmonic tones; this could be due to lateral inhibition strongly influencing the MMN elicited by harmonic tones but having less effect on the MMN elicited by pure tones. As lateral inhibition is a neural mechanism for attenuating the amplitude of MMN, our results support the notion that an enhanced lateral inhibition mechanism underlies superior pitch discrimination.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres-
dc.relation.ispartofBrain Research-
dc.subjectMismatch negativity-
dc.subjectPitch perception-
dc.subjectLateral inhibition-
dc.subjectAuditory discriminationTonotopy-
dc.subjectOddball paradigm-
dc.titleA Lateral Inhibition Mechanism Explains the Dissociation between Mismatch Negativity and Behavioral Pitch Discrimination-
dc.typeArticle-
dc.identifier.emailGu, F: gufeng@hku.hk-
dc.identifier.emailWong, L: llnwong@hku.hk-
dc.identifier.emailTong, X: xltong@hku.hk-
dc.identifier.authorityWong, L=rp00975-
dc.identifier.authorityTong, X=rp01546-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2019.146308-
dc.identifier.pmid31247205-
dc.identifier.scopuseid_2-s2.0-85067867364-
dc.identifier.hkuros299890-
dc.identifier.volume1720-
dc.identifier.spagearticle no. 146308-
dc.identifier.epagearticle no. 146308-
dc.publisher.placeNetherlands-

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