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Article: Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant

TitleRat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant
Authors
Sridhar, SYip, CCYWu, SCai, JZhang, AJXLeung, KHChung, TWHChan, JFWChan, WMTeng, LLAu-Yeung, RKHCheng, VCCChen, HLau, SKPWoo, PCYXia, NSLo, CMYuen, KY
Keywordsacute hepatitis
adult
bronchiectasis
case report
chronic obstructive lung disease
Issue Date2018
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2018, v. 24 n. 12, p. 2241-2250 How to Cite?
DOI: http://dx.doi.org/10.3201/eid2412.180937
AbstractAll hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.
Persistent Identifierhttp://hdl.handle.net/10722/272102
ISSN
1080-6040
2021 Impact Factor: 16.126
2020 SCImago Journal Rankings: 2.540
PubMed Central ID
PMC6256372
ISI Accession Number ID
WOS:000450617500013

 

DC FieldValueLanguage
dc.contributor.authorSridhar, S-
dc.contributor.authorYip, CCY-
dc.contributor.authorWu, S-
dc.contributor.authorCai, J-
dc.contributor.authorZhang, AJX-
dc.contributor.authorLeung, KH-
dc.contributor.authorChung, TWH-
dc.contributor.authorChan, JFW-
dc.contributor.authorChan, WM-
dc.contributor.authorTeng, LL-
dc.contributor.authorAu-Yeung, RKH-
dc.contributor.authorCheng, VCC-
dc.contributor.authorChen, H-
dc.contributor.authorLau, SKP-
dc.contributor.authorWoo, PCY-
dc.contributor.authorXia, NS-
dc.contributor.authorLo, CM-
dc.contributor.authorYuen, KY-
dc.date.accessioned2019-07-20T10:35:43Z-
dc.date.available2019-07-20T10:35:43Z-
dc.date.issued2018-
dc.identifier.citationEmerging Infectious Diseases, 2018, v. 24 n. 12, p. 2241-2250-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/272102-
dc.description.abstractAll hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.subjectacute hepatitis-
dc.subjectadult-
dc.subjectbronchiectasis-
dc.subjectcase report-
dc.subjectchronic obstructive lung disease-
dc.titleRat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant-
dc.typeArticle-
dc.identifier.emailSridhar, S: sid8998@hku.hk-
dc.identifier.emailYip, CCY: yipcyril@hku.hk-
dc.identifier.emailWu, S: wss2017@hku.hk-
dc.identifier.emailCai, J: caijuice@hku.hk-
dc.identifier.emailZhang, AJX: zhangajx@hkucc.hku.hk-
dc.identifier.emailLeung, KH: khl17@hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailChan, WM: mbally@hku.hk-
dc.identifier.emailTeng, LL: llteng@hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authoritySridhar, S=rp02249-
dc.identifier.authorityYip, CCY=rp01721-
dc.identifier.authorityZhang, AJX=rp00413-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityTeng, LL=rp00277-
dc.identifier.authorityChen, H=rp00383-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2412.180937-
dc.identifier.pmid30457530-
dc.identifier.pmcidPMC6256372-
dc.identifier.scopuseid_2-s2.0-85056699274-
dc.identifier.hkuros298351-
dc.identifier.volume24-
dc.identifier.issue12-
dc.identifier.spage2241-
dc.identifier.epage2250-
dc.identifier.isiWOS:000450617500013-
dc.publisher.placeUnited States-
dc.identifier.issnl1080-6040-

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