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Conference Paper: In vivo MRI detection of early ß-amyloid pathologies targeted by curcumin-conjugated magnetic nanoparticles
| Title | In vivo MRI detection of early ß-amyloid pathologies targeted by curcumin-conjugated magnetic nanoparticles |
|---|---|
| Authors | |
| Issue Date | 2018 |
| Publisher | International Society for Magnetic Resonance in Medicine. |
| Citation | Proceedings of International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Joint Annual Meeting, Paris, France, 16-21 June 2018, abstract no. 1089 How to Cite? |
| Abstract | Early state β-amyloid oligomers (AβOs) and late stage Aβ plaques are the pathological hallmarks of Alzheimer's disease (AD) brains, and they can be targeted by curcumin. We have recently designed and synthesized a new curcumin-conjugated magnetic nanoparticles (Cur-MNPs) to target these Aβ pathologies. In this study, we aimed to assess this novel Cur-MNPs based MRI contrast agent for its in vivo ability to detect and visualize the Aβ pathologies during both very early and late stage of AD progression in AD mouse models. |
| Description | Special Session: Highlights of the Joint Annual Meeting ISMRM-ESMRMB - Oral Presentation -no. 1089 |
| Persistent Identifier | http://hdl.handle.net/10722/260714 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Dong, CM | - |
| dc.contributor.author | To, KWA | - |
| dc.contributor.author | Wong, ECS | - |
| dc.contributor.author | Wu, EX | - |
| dc.date.accessioned | 2018-09-14T08:46:12Z | - |
| dc.date.available | 2018-09-14T08:46:12Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.citation | Proceedings of International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Joint Annual Meeting, Paris, France, 16-21 June 2018, abstract no. 1089 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/260714 | - |
| dc.description | Special Session: Highlights of the Joint Annual Meeting ISMRM-ESMRMB - Oral Presentation -no. 1089 | - |
| dc.description.abstract | Early state β-amyloid oligomers (AβOs) and late stage Aβ plaques are the pathological hallmarks of Alzheimer's disease (AD) brains, and they can be targeted by curcumin. We have recently designed and synthesized a new curcumin-conjugated magnetic nanoparticles (Cur-MNPs) to target these Aβ pathologies. In this study, we aimed to assess this novel Cur-MNPs based MRI contrast agent for its in vivo ability to detect and visualize the Aβ pathologies during both very early and late stage of AD progression in AD mouse models. | - |
| dc.language | eng | - |
| dc.publisher | International Society for Magnetic Resonance in Medicine. | - |
| dc.relation.ispartof | ISMRM-ESMRMB Joint Annual Meeting 2018 | - |
| dc.title | In vivo MRI detection of early ß-amyloid pathologies targeted by curcumin-conjugated magnetic nanoparticles | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | To, KWA: toanthea@hku.hk | - |
| dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
| dc.identifier.authority | Wu, EX=rp00193 | - |
| dc.identifier.hkuros | 291492 | - |
| dc.identifier.spage | abstract no. 1089 | - |
| dc.identifier.epage | abstract no. 1089 | - |
| dc.publisher.place | United States | - |