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- Publisher Website: 10.1016/j.maturitas.2018.05.011
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- PMID: 29907245
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Article: Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study
Title | Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study |
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Authors | |
Keywords | Association Diabetes Follicle stimulating hormone (FSH) Menopause |
Issue Date | 2018 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas |
Citation | Maturitas, 2018, v. 114, p. 41-45 How to Cite? |
Abstract | Menopause is an important transition of reproductive stage in a woman's life. It is associated with diabetes, but the role of follicle stimulating hormone (FSH), a menopause-related hormone, in the risk of diabetes is largely unknown. We evaluated the relationship between serum FSH and diabetes in 1274 participants from the Hong Kong Osteoporosis Study aged≥55 at baseline. We also searched relevant databases for studies on serum FSH and incident diabetes and conducted a meta-analysis using fixed-effect modeling. Cases of incident diabetes (N = 60) were ascertained during a median follow-up of 10.7 years. Serum FSH was significantly associated with reduced risk of diabetes in both a crude model (hazard ratio [HR] per SD increase: 0.66; 95% CI: 0.48-0.89; P = 0.007) and a full model with adjustment for age, sex, body mass index, factors related to risk of diabetes, and reproductive health (HR per SD increase: 0.70; 95% CI: 0.51-0.97; P = 0.030); a similar result was observed when FSH was analysed in quintiles. In a fixed-effect meta-analysis of two studies, including the current study, serum FSH > 50 IU/L was associated with reduced risk of diabetes (HR = 0.56; 95% CI: 0.36-0.85; P = 0.006; I2 = 0). In conclusion, serum FSH levels were independently associated with diabetes. |
Persistent Identifier | http://hdl.handle.net/10722/260524 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.280 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheung, CL | - |
dc.contributor.author | Kung, AWC | - |
dc.contributor.author | Tan, KCB | - |
dc.date.accessioned | 2018-09-14T08:43:06Z | - |
dc.date.available | 2018-09-14T08:43:06Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Maturitas, 2018, v. 114, p. 41-45 | - |
dc.identifier.issn | 0378-5122 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260524 | - |
dc.description.abstract | Menopause is an important transition of reproductive stage in a woman's life. It is associated with diabetes, but the role of follicle stimulating hormone (FSH), a menopause-related hormone, in the risk of diabetes is largely unknown. We evaluated the relationship between serum FSH and diabetes in 1274 participants from the Hong Kong Osteoporosis Study aged≥55 at baseline. We also searched relevant databases for studies on serum FSH and incident diabetes and conducted a meta-analysis using fixed-effect modeling. Cases of incident diabetes (N = 60) were ascertained during a median follow-up of 10.7 years. Serum FSH was significantly associated with reduced risk of diabetes in both a crude model (hazard ratio [HR] per SD increase: 0.66; 95% CI: 0.48-0.89; P = 0.007) and a full model with adjustment for age, sex, body mass index, factors related to risk of diabetes, and reproductive health (HR per SD increase: 0.70; 95% CI: 0.51-0.97; P = 0.030); a similar result was observed when FSH was analysed in quintiles. In a fixed-effect meta-analysis of two studies, including the current study, serum FSH > 50 IU/L was associated with reduced risk of diabetes (HR = 0.56; 95% CI: 0.36-0.85; P = 0.006; I2 = 0). In conclusion, serum FSH levels were independently associated with diabetes. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas | - |
dc.relation.ispartof | Maturitas | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Association | - |
dc.subject | Diabetes | - |
dc.subject | Follicle stimulating hormone (FSH) | - |
dc.subject | Menopause | - |
dc.title | Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study | - |
dc.type | Article | - |
dc.identifier.email | Cheung, CL: lung1212@hku.hk | - |
dc.identifier.email | Kung, AWC: awckung@hku.hk | - |
dc.identifier.email | Tan, KCB: kcbtan@hkucc.hku.hk | - |
dc.identifier.authority | Cheung, CL=rp01749 | - |
dc.identifier.authority | Kung, AWC=rp00368 | - |
dc.identifier.authority | Tan, KCB=rp00402 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.maturitas.2018.05.011 | - |
dc.identifier.pmid | 29907245 | - |
dc.identifier.scopus | eid_2-s2.0-85047870400 | - |
dc.identifier.hkuros | 290697 | - |
dc.identifier.volume | 114 | - |
dc.identifier.spage | 41 | - |
dc.identifier.epage | 45 | - |
dc.identifier.isi | WOS:000437957200007 | - |
dc.publisher.place | Ireland | - |
dc.identifier.issnl | 0378-5122 | - |