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Article: Left atrial mechanics and integrated calibrated backscatter in anthracycline-treated long-term survivors of childhood cancers

TitleLeft atrial mechanics and integrated calibrated backscatter in anthracycline-treated long-term survivors of childhood cancers
Authors
KeywordsCalibrated integrated backscatter
Childhood cancer survivors
Left atrial mechanics
Ultrasound
Issue Date2017
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ultrasmedbio
Citation
Ultrasound in Medicine and Biology, 2017, v. 43 n. 9, p. 1897-1905 How to Cite?
AbstractWe tested the hypothesis that left atrial (LA) mechanics and myocardial calibrated integrated backscatter (cIB) are altered in anthracycline-treated long-term survivors of childhood cancers. Forty-nine survivors and 25 controls were studied. Survivors had significantly smaller maximal (p = 0.009) and minimal (p = 0.017) LA volumes and lower peak negative LA strains (p = 0.011). For left ventricular (LV) indices, survivors had significantly lower shortening fraction (p < 0.001), ejection fraction (p < 0.001) and mitral annular late diastolic velocity (p = 0.003). Myocardial cIB of the LA posterior wall, ventricular septum and LV posterior wall was significantly greater in survivors than controls (all p values <0.05). Peak negative LA strain was related to late diastolic mitral annular velocity (r = 0.27, p = 0.018), whereas LA cIB was related to the average of septal and LV posterior wall cIB (r = 0.54, p < 0.001). In conclusion, LA remodeling as characterized by contractile dysfunction and increased cIB suggestive of fibrosis occurs in adult survivors of childhood cancers. © 2017 World Federation for Ultrasound in Medicine & Biology
Persistent Identifierhttp://hdl.handle.net/10722/249295
ISSN
2019 Impact Factor: 2.514
2015 SCImago Journal Rankings: 0.885
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLI, WYV-
dc.contributor.authorLai, CTM-
dc.contributor.authorLiu, APY-
dc.contributor.authorCheuk, KLD-
dc.contributor.authorCheung, YF-
dc.date.accessioned2017-11-21T03:00:11Z-
dc.date.available2017-11-21T03:00:11Z-
dc.date.issued2017-
dc.identifier.citationUltrasound in Medicine and Biology, 2017, v. 43 n. 9, p. 1897-1905-
dc.identifier.issn0301-5629-
dc.identifier.urihttp://hdl.handle.net/10722/249295-
dc.description.abstractWe tested the hypothesis that left atrial (LA) mechanics and myocardial calibrated integrated backscatter (cIB) are altered in anthracycline-treated long-term survivors of childhood cancers. Forty-nine survivors and 25 controls were studied. Survivors had significantly smaller maximal (p = 0.009) and minimal (p = 0.017) LA volumes and lower peak negative LA strains (p = 0.011). For left ventricular (LV) indices, survivors had significantly lower shortening fraction (p < 0.001), ejection fraction (p < 0.001) and mitral annular late diastolic velocity (p = 0.003). Myocardial cIB of the LA posterior wall, ventricular septum and LV posterior wall was significantly greater in survivors than controls (all p values <0.05). Peak negative LA strain was related to late diastolic mitral annular velocity (r = 0.27, p = 0.018), whereas LA cIB was related to the average of septal and LV posterior wall cIB (r = 0.54, p < 0.001). In conclusion, LA remodeling as characterized by contractile dysfunction and increased cIB suggestive of fibrosis occurs in adult survivors of childhood cancers. © 2017 World Federation for Ultrasound in Medicine & Biology-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ultrasmedbio-
dc.relation.ispartofUltrasound in Medicine and Biology-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectCalibrated integrated backscatter-
dc.subjectChildhood cancer survivors-
dc.subjectLeft atrial mechanics-
dc.subjectUltrasound-
dc.titleLeft atrial mechanics and integrated calibrated backscatter in anthracycline-treated long-term survivors of childhood cancers-
dc.typeArticle-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityLiu, APY=rp01357-
dc.identifier.authorityCheung, YF=rp00382-
dc.identifier.doi10.1016/j.ultrasmedbio.2017.05.017-
dc.identifier.scopuseid_2-s2.0-85020866276-
dc.identifier.hkuros283155-
dc.identifier.volume43-
dc.identifier.issue9-
dc.identifier.spage1897-
dc.identifier.epage1905-
dc.identifier.isiWOS:000406420200017-
dc.publisher.placeUnited States-

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