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Conference Paper: Low Frequency Hippocampal-Cortical Activity Contributes to Brain-Wide Connectivity as Measured by Resting-State fMRI
Title | Low Frequency Hippocampal-Cortical Activity Contributes to Brain-Wide Connectivity as Measured by Resting-State fMRI |
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Authors | |
Issue Date | 2017 |
Publisher | The International Society for Magnetic Resonance in Medicine. |
Citation | The International Society of Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition, Honolulu, HI, USA, 22-27 April 2017 How to Cite? |
Abstract | The hippocampus, including dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low frequency activities in hippocampal-cortical pathway underlie brain-wide resting-state fMRI (rsfMRI) connectivity to mediate distinct cognitive functions and integrate sensory information. Using optogenetics and fMRI, we determined large-scale spatiotemporal specific hippocampal-cortical activity. Low, but not high, frequency optogenetic stimulation of dDG excitatory neurons evoked robust cortical and subcortical responses, and enhanced interhemispheric hippocampal and cortical rsfMRI connectivity. In addition, pharmacological inactivation of dDG decreased rsfMRI connectivity. These findings directly indicate that low frequency activity propagates in hippocampal-cortical pathway and contributes to brain-wide rsfMRI connectivity. |
Description | Oral Scientific Session: fMRI: Multimodal & Neuromodulation |
Persistent Identifier | http://hdl.handle.net/10722/247799 |
DC Field | Value | Language |
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dc.contributor.author | Chan, RW | - |
dc.contributor.author | Leong, TL | - |
dc.contributor.author | Ho, CC | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | To, KWA | - |
dc.contributor.author | Wu, EX | - |
dc.date.accessioned | 2017-10-18T08:32:51Z | - |
dc.date.available | 2017-10-18T08:32:51Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | The International Society of Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition, Honolulu, HI, USA, 22-27 April 2017 | - |
dc.identifier.uri | http://hdl.handle.net/10722/247799 | - |
dc.description | Oral Scientific Session: fMRI: Multimodal & Neuromodulation | - |
dc.description.abstract | The hippocampus, including dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low frequency activities in hippocampal-cortical pathway underlie brain-wide resting-state fMRI (rsfMRI) connectivity to mediate distinct cognitive functions and integrate sensory information. Using optogenetics and fMRI, we determined large-scale spatiotemporal specific hippocampal-cortical activity. Low, but not high, frequency optogenetic stimulation of dDG excitatory neurons evoked robust cortical and subcortical responses, and enhanced interhemispheric hippocampal and cortical rsfMRI connectivity. In addition, pharmacological inactivation of dDG decreased rsfMRI connectivity. These findings directly indicate that low frequency activity propagates in hippocampal-cortical pathway and contributes to brain-wide rsfMRI connectivity. | - |
dc.language | eng | - |
dc.publisher | The International Society for Magnetic Resonance in Medicine. | - |
dc.relation.ispartof | ISMRM 2017 Annual Meeting & Exhibition | - |
dc.title | Low Frequency Hippocampal-Cortical Activity Contributes to Brain-Wide Connectivity as Measured by Resting-State fMRI | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, RW: russchan@connect.hku.hk | - |
dc.identifier.email | Leong, TL: tlleong@hku.hk | - |
dc.identifier.email | To, KWA: toanthea@hku.hk | - |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
dc.identifier.authority | Wu, EX=rp00193 | - |
dc.identifier.hkuros | 280419 | - |
dc.publisher.place | United States | - |