File Download

There are no files associated with this item.

Supplementary

Conference Paper: Low Frequency Hippocampal-Cortical Activity Contributes to Brain-Wide Connectivity as Measured by Resting-State fMRI

TitleLow Frequency Hippocampal-Cortical Activity Contributes to Brain-Wide Connectivity as Measured by Resting-State fMRI
Authors
Issue Date2017
PublisherThe International Society for Magnetic Resonance in Medicine.
Citation
The International Society of Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition, Honolulu, HI, USA, 22-27 April 2017 How to Cite?
AbstractThe hippocampus, including dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low frequency activities in hippocampal-cortical pathway underlie brain-wide resting-state fMRI (rsfMRI) connectivity to mediate distinct cognitive functions and integrate sensory information. Using optogenetics and fMRI, we determined large-scale spatiotemporal specific hippocampal-cortical activity. Low, but not high, frequency optogenetic stimulation of dDG excitatory neurons evoked robust cortical and subcortical responses, and enhanced interhemispheric hippocampal and cortical rsfMRI connectivity. In addition, pharmacological inactivation of dDG decreased rsfMRI connectivity. These findings directly indicate that low frequency activity propagates in hippocampal-cortical pathway and contributes to brain-wide rsfMRI connectivity.
DescriptionOral Scientific Session: fMRI: Multimodal & Neuromodulation
Persistent Identifierhttp://hdl.handle.net/10722/247799

 

DC FieldValueLanguage
dc.contributor.authorChan, RW-
dc.contributor.authorLeong, TL-
dc.contributor.authorHo, CC-
dc.contributor.authorWang, X-
dc.contributor.authorTo, KWA-
dc.contributor.authorWu, EX-
dc.date.accessioned2017-10-18T08:32:51Z-
dc.date.available2017-10-18T08:32:51Z-
dc.date.issued2017-
dc.identifier.citationThe International Society of Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition, Honolulu, HI, USA, 22-27 April 2017-
dc.identifier.urihttp://hdl.handle.net/10722/247799-
dc.descriptionOral Scientific Session: fMRI: Multimodal & Neuromodulation-
dc.description.abstractThe hippocampus, including dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low frequency activities in hippocampal-cortical pathway underlie brain-wide resting-state fMRI (rsfMRI) connectivity to mediate distinct cognitive functions and integrate sensory information. Using optogenetics and fMRI, we determined large-scale spatiotemporal specific hippocampal-cortical activity. Low, but not high, frequency optogenetic stimulation of dDG excitatory neurons evoked robust cortical and subcortical responses, and enhanced interhemispheric hippocampal and cortical rsfMRI connectivity. In addition, pharmacological inactivation of dDG decreased rsfMRI connectivity. These findings directly indicate that low frequency activity propagates in hippocampal-cortical pathway and contributes to brain-wide rsfMRI connectivity.-
dc.languageeng-
dc.publisherThe International Society for Magnetic Resonance in Medicine.-
dc.relation.ispartofISMRM 2017 Annual Meeting & Exhibition-
dc.titleLow Frequency Hippocampal-Cortical Activity Contributes to Brain-Wide Connectivity as Measured by Resting-State fMRI-
dc.typeConference_Paper-
dc.identifier.emailChan, RW: russchan@connect.hku.hk-
dc.identifier.emailLeong, TL: tlleong@hku.hk-
dc.identifier.emailTo, KWA: toanthea@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193-
dc.identifier.hkuros280419-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats