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Article: Circulating Microrna In Patients With Repaired Tetralogy Of Fallot

TitleCirculating Microrna In Patients With Repaired Tetralogy Of Fallot
Authors
Issue Date2017
PublisherWiley for Stichting European Society for Clinical Investigation Journal Foundation. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2362
Citation
European Journal of Clinical Investigation (EJCI), 2017, v. 47, p. 574-582 How to Cite?
AbstractBACKGROUND: Emerging data suggest that heart-related microRNAs (miRs) may serve as circulating biomarkers of myocardial injury. We aimed to determine the circulating profile of miRs in patients with volume-overloaded right ventricles after repair of tetralogy (TOF). MATERIALS AND METHODS: A total of 104 TOF patients and 70 controls were recruited. The study was conducted in two phases: (1) determination of circulating heart-related miRs described in left heart diseases (miR-1, miR-133a, miR-208a, miR-208b and miR423-5p) by quantitative real-time PCR in 49 patients and 30 controls and followed by validation in an independent cohort of 55 patients and 40 controls; (2) expression profiling of serum samples from eight patients and eight controls, followed by validation. Alteration in circulating miRNA expression was related to cardiac functional indices as assessed by 2D speckle tracking and 3D echocardiography. RESULTS: No significant differences in serum levels of left heart-associated miRNAs were found between patients and controls. Of the candidate 19 miRNAs identified by profiling, upregulation of miR-99b and down-regulation of miR-766 were validated. However, no correlations were found between miRs levels and echo indices. CONCLUSION: In young adults with repaired TOF and volume-overloaded right ventricles, circulating levels of miR-99b and miR-766, but not left heart-associated miRNAs, were significantly altered.
Persistent Identifierhttp://hdl.handle.net/10722/245307
ISSN
2019 Impact Factor: 3.481
2015 SCImago Journal Rankings: 1.255
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, CTM-
dc.contributor.authorNg, EKO-
dc.contributor.authorChow, PC-
dc.contributor.authorKwong, A-
dc.contributor.authorCheung, YF-
dc.date.accessioned2017-09-18T02:08:18Z-
dc.date.available2017-09-18T02:08:18Z-
dc.date.issued2017-
dc.identifier.citationEuropean Journal of Clinical Investigation (EJCI), 2017, v. 47, p. 574-582-
dc.identifier.issn0014-2972-
dc.identifier.urihttp://hdl.handle.net/10722/245307-
dc.description.abstractBACKGROUND: Emerging data suggest that heart-related microRNAs (miRs) may serve as circulating biomarkers of myocardial injury. We aimed to determine the circulating profile of miRs in patients with volume-overloaded right ventricles after repair of tetralogy (TOF). MATERIALS AND METHODS: A total of 104 TOF patients and 70 controls were recruited. The study was conducted in two phases: (1) determination of circulating heart-related miRs described in left heart diseases (miR-1, miR-133a, miR-208a, miR-208b and miR423-5p) by quantitative real-time PCR in 49 patients and 30 controls and followed by validation in an independent cohort of 55 patients and 40 controls; (2) expression profiling of serum samples from eight patients and eight controls, followed by validation. Alteration in circulating miRNA expression was related to cardiac functional indices as assessed by 2D speckle tracking and 3D echocardiography. RESULTS: No significant differences in serum levels of left heart-associated miRNAs were found between patients and controls. Of the candidate 19 miRNAs identified by profiling, upregulation of miR-99b and down-regulation of miR-766 were validated. However, no correlations were found between miRs levels and echo indices. CONCLUSION: In young adults with repaired TOF and volume-overloaded right ventricles, circulating levels of miR-99b and miR-766, but not left heart-associated miRNAs, were significantly altered.-
dc.languageeng-
dc.publisherWiley for Stichting European Society for Clinical Investigation Journal Foundation. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2362-
dc.relation.ispartofEuropean Journal of Clinical Investigation (EJCI)-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving: http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms-
dc.titleCirculating Microrna In Patients With Repaired Tetralogy Of Fallot-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.identifier.doi10.1111/eci.12778-
dc.identifier.hkuros275648-
dc.identifier.hkuros283154-
dc.identifier.volume47-
dc.identifier.spage574-
dc.identifier.epage582-
dc.identifier.isiWOS:000406293500004-
dc.publisher.placeUnited Kingdom-

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