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Conference Paper: Differential prediction profiles of amotivation and diminished expression in first-episode psychosis: 12-month follow-up of the randomized-controlled trial on extended early intervention in Hong Kong

TitleDifferential prediction profiles of amotivation and diminished expression in first-episode psychosis: 12-month follow-up of the randomized-controlled trial on extended early intervention in Hong Kong
Authors
Issue Date2016
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893
Citation
The IEPA 10th International Conference on Early Intervention in Mental Health, Milan, Italy, 20-22 October 2016. In Early Intervention in Psychiatry, 2006, v. 10 suppl. S1, p. 137, abstarct no. A68 How to Cite?
AbstractAmotivation and diminished expression (DE) are two distinct dimensions underlying negative symptom construct and may be differentially predicted by illness variables in first-episode psychosis (FEP). We aimed to examine clinical and treatment-related determinants of amotivation and DE in FEP patients in the context of a randomizedcontrolled trial (RCT) comparing 1-year extended early intervention (Extended EI, 3-year EI) with step-down psychiatric care (SC, 2-year EI) in Hong Kong. One hundred sixty Chinese patients were recruited from a specialized program for FEP (EASY) after they had completed this 2-year EI service, randomly allocated to Extended EI or SC, and followed up for 12 months. Assessments on premorbid adjustment, clinical and treatment characteristics were conducted. Amotivation and DE scores were derived from PANSS items based on previous factor analytic studies. Correlations and independent t-tests were performed as appropriate followed by multiple linear regression analyses to determine predictors of amotivation and DE at follow-up. Data analysis was based on 156 subjects who completed follow-up assessments. Our results showed that Extended EI treatment, DE and depressive symptom ratings at intake independently predicted amotivation at 12 months (Adjusted R2=0.19, p<0.001). DE at 12-month follow-up was predicted by educational level, DE and PANSS excitement scores at intake (Adjusted R2=0.16, p<0.001). Our study revealed different predictor profiles for DE and amotivation. In particular, Extended EI predicted amotivation but not DE levels at 12-month follow-up, highlighting the presence of differential treatment responses of two negative symptom dimensions toward EI in FEP patients.
DescriptionConference Theme: Looking Back, Moving Forward
Poster Abstracts: no. A68
This free journal suppl. entitled: Special Issue: IEPA 10th International Conference on Early Intervention in Mental Health ... 2016
Persistent Identifierhttp://hdl.handle.net/10722/236948
ISSN
2020 Impact Factor: 2.732
2020 SCImago Journal Rankings: 1.087

 

DC FieldValueLanguage
dc.contributor.authorChang, WC-
dc.contributor.authorKwong, VWY-
dc.contributor.authorChan, HKG-
dc.contributor.authorJim, OTT-
dc.contributor.authorLau, ESK-
dc.contributor.authorHui, CLM-
dc.contributor.authorChan, KWS-
dc.contributor.authorLee, HME-
dc.contributor.authorChen, EYH-
dc.date.accessioned2016-12-20T04:21:52Z-
dc.date.available2016-12-20T04:21:52Z-
dc.date.issued2016-
dc.identifier.citationThe IEPA 10th International Conference on Early Intervention in Mental Health, Milan, Italy, 20-22 October 2016. In Early Intervention in Psychiatry, 2006, v. 10 suppl. S1, p. 137, abstarct no. A68-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/236948-
dc.descriptionConference Theme: Looking Back, Moving Forward-
dc.descriptionPoster Abstracts: no. A68-
dc.descriptionThis free journal suppl. entitled: Special Issue: IEPA 10th International Conference on Early Intervention in Mental Health ... 2016-
dc.description.abstractAmotivation and diminished expression (DE) are two distinct dimensions underlying negative symptom construct and may be differentially predicted by illness variables in first-episode psychosis (FEP). We aimed to examine clinical and treatment-related determinants of amotivation and DE in FEP patients in the context of a randomizedcontrolled trial (RCT) comparing 1-year extended early intervention (Extended EI, 3-year EI) with step-down psychiatric care (SC, 2-year EI) in Hong Kong. One hundred sixty Chinese patients were recruited from a specialized program for FEP (EASY) after they had completed this 2-year EI service, randomly allocated to Extended EI or SC, and followed up for 12 months. Assessments on premorbid adjustment, clinical and treatment characteristics were conducted. Amotivation and DE scores were derived from PANSS items based on previous factor analytic studies. Correlations and independent t-tests were performed as appropriate followed by multiple linear regression analyses to determine predictors of amotivation and DE at follow-up. Data analysis was based on 156 subjects who completed follow-up assessments. Our results showed that Extended EI treatment, DE and depressive symptom ratings at intake independently predicted amotivation at 12 months (Adjusted R2=0.19, p<0.001). DE at 12-month follow-up was predicted by educational level, DE and PANSS excitement scores at intake (Adjusted R2=0.16, p<0.001). Our study revealed different predictor profiles for DE and amotivation. In particular, Extended EI predicted amotivation but not DE levels at 12-month follow-up, highlighting the presence of differential treatment responses of two negative symptom dimensions toward EI in FEP patients.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.titleDifferential prediction profiles of amotivation and diminished expression in first-episode psychosis: 12-month follow-up of the randomized-controlled trial on extended early intervention in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailKwong, VWY: vivikwy@hku.hk-
dc.identifier.emailChan, HKG: cgloria@hku.hk-
dc.identifier.emailJim, OTT: olijim@hku.hk-
dc.identifier.emailLau, ESK: sinkilau@hku.hk-
dc.identifier.emailHui, CLM: christyh@hkucc.hku.hk-
dc.identifier.emailChan, KWS: kwsherry@hku.hk-
dc.identifier.emailLee, HME: edwinlhm@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityHui, CLM=rp01993-
dc.identifier.authorityChan, KWS=rp00539-
dc.identifier.authorityLee, HME=rp01575-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/eip.12397-
dc.identifier.hkuros270890-
dc.identifier.volume10-
dc.identifier.issuesuppl. S1-
dc.identifier.spage137, abstarct no. A68-
dc.identifier.epage137, abstarct no. A68-
dc.publisher.placeUnited States-
dc.identifier.issnl1751-7885-

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