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Conference Paper: Determinants of subjective quality of life in first-episode psychosis patients receiving specialized early intervention service in Hong Kong

TitleDeterminants of subjective quality of life in first-episode psychosis patients receiving specialized early intervention service in Hong Kong
Authors
Issue Date2016
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893
Citation
The IEPA 10th International Conference on Early Intervention in Mental Health, Milan, Italy, 20-22 October 2016. In Early Intervention in Psychiatry, 2016, v. 10 suppl. S1, p. 142, abstract no. A86 How to Cite?
AbstractSubjective health-related quality of life (QoL) is an important outcome dimension in patients with schizophrenia and related psychoses, but is relatively less studied in the early stage of illness. We aimed to examine clinical and treatment-related correlates of subjective QoL in 159 Chinese patients who had received 2-years of treatment from a specialized early intervention service (EASY) in Hong Kong. This was part of a randomized-controlled trial evaluating the efficacy of 1-year extended early intervention for first-episode psychosis (FEP) and the analyses were based on data obtained at study entry. Standardized assessments encompassing premorbid adjustment, duration of untreated psychosis, symptomatology, functioning and medication treatments were conducted. SF36 was administered with mental and physical health summary (MCS and PCS) scores being computed as primary measures for QoL. Correlations and independent t-test were performed as appropriate followed by multiple linear regression analyses to determine predictors of MCS and PCS scores. Our results showed that positive symptoms, depression, social anxiety, akathisia and attitude toward antipsychotic independently predicted MCS score (Adjusted R2=0.48, F=26.44, p<0.001). PCS score was predicted by social anxiety and functional levels (Adjusted R2=0.12, F=11.55, p<0.001). In line with the literature, our study indicates that psychopathology, in particular depression and anxiety are the major determinants of subjective QoL in FEP patients. Clinical staff should also adequately address antipsychotic-induced extrapyramidal side-effects and patients’ negative attitudes toward medication treatment in order to further improve subjective QoL of patients in the early stage of illness.
DescriptionConference Theme: Looking Back, Moving Forward
Poster Abstracts: no. A86
This free journal suppl. entitled: Special Issue: IEPA 10th International Conference on Early Intervention in Mental Health ... 2016
Persistent Identifierhttp://hdl.handle.net/10722/236947
ISSN
2020 Impact Factor: 2.732
2020 SCImago Journal Rankings: 1.087

 

DC FieldValueLanguage
dc.contributor.authorKwong, VWY-
dc.contributor.authorChang, WC-
dc.contributor.authorChan, HKG-
dc.contributor.authorJim, OTT-
dc.contributor.authorLau, ESK-
dc.contributor.authorHui, CLM-
dc.contributor.authorChan, KWS-
dc.contributor.authorLee, EHM-
dc.contributor.authorChen, E-
dc.date.accessioned2016-12-20T04:06:56Z-
dc.date.available2016-12-20T04:06:56Z-
dc.date.issued2016-
dc.identifier.citationThe IEPA 10th International Conference on Early Intervention in Mental Health, Milan, Italy, 20-22 October 2016. In Early Intervention in Psychiatry, 2016, v. 10 suppl. S1, p. 142, abstract no. A86-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/236947-
dc.descriptionConference Theme: Looking Back, Moving Forward-
dc.descriptionPoster Abstracts: no. A86-
dc.descriptionThis free journal suppl. entitled: Special Issue: IEPA 10th International Conference on Early Intervention in Mental Health ... 2016-
dc.description.abstractSubjective health-related quality of life (QoL) is an important outcome dimension in patients with schizophrenia and related psychoses, but is relatively less studied in the early stage of illness. We aimed to examine clinical and treatment-related correlates of subjective QoL in 159 Chinese patients who had received 2-years of treatment from a specialized early intervention service (EASY) in Hong Kong. This was part of a randomized-controlled trial evaluating the efficacy of 1-year extended early intervention for first-episode psychosis (FEP) and the analyses were based on data obtained at study entry. Standardized assessments encompassing premorbid adjustment, duration of untreated psychosis, symptomatology, functioning and medication treatments were conducted. SF36 was administered with mental and physical health summary (MCS and PCS) scores being computed as primary measures for QoL. Correlations and independent t-test were performed as appropriate followed by multiple linear regression analyses to determine predictors of MCS and PCS scores. Our results showed that positive symptoms, depression, social anxiety, akathisia and attitude toward antipsychotic independently predicted MCS score (Adjusted R2=0.48, F=26.44, p<0.001). PCS score was predicted by social anxiety and functional levels (Adjusted R2=0.12, F=11.55, p<0.001). In line with the literature, our study indicates that psychopathology, in particular depression and anxiety are the major determinants of subjective QoL in FEP patients. Clinical staff should also adequately address antipsychotic-induced extrapyramidal side-effects and patients’ negative attitudes toward medication treatment in order to further improve subjective QoL of patients in the early stage of illness.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.titleDeterminants of subjective quality of life in first-episode psychosis patients receiving specialized early intervention service in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailKwong, VWY: vivikwy@hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailChan, HKG: cgloria@hku.hk-
dc.identifier.emailJim, OTT: olijim@hku.hk-
dc.identifier.emailLau, ESK: sinkilau@hku.hk-
dc.identifier.emailHui, CLM: clmhui@hku.hk-
dc.identifier.emailChan, KWS: kwsherry@hku.hk-
dc.identifier.emailLee, EHM: edwinlhm@hku.hk-
dc.identifier.emailChen, E: eyhchen@hku.hk-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityHui, CLM=rp01993-
dc.identifier.authorityChan, KWS=rp00539-
dc.identifier.authorityLee, EHM=rp01575-
dc.identifier.authorityChen, E=rp00392-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/eip.12397-
dc.identifier.hkuros270895-
dc.identifier.hkuros272718-
dc.identifier.volume10-
dc.identifier.issuesuppl. S1-
dc.identifier.spage142, abstract no. A86-
dc.identifier.epage142, abstract no. A86-
dc.publisher.placeUnited States-
dc.identifier.issnl1751-7885-

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