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- Publisher Website: 10.1093/infdis/jiw346
- Scopus: eid_2-s2.0-84990909246
- PMID: 27493238
- WOS: WOS:000386147200008
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Article: Preexisting Antibody-Dependent Cellular Cytotoxicity–Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure
Title | Preexisting Antibody-Dependent Cellular Cytotoxicity–Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure |
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Authors | |
Keywords | Influenza Antibody ADCC NK cells |
Issue Date | 2016 |
Publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/ |
Citation | Journal of Infectious Diseases, 2016, v. 214 n. 8, p. 1159-1163 How to Cite? |
Abstract | Cross-reactive influenza virus-specific antibody-dependent cellular cytotoxicity (ADCC)-activating antibodies are readily detected in healthy adults. However, little is known about the kinetics of these ADCC responses. We used retrospective serial blood samples from healthy donors to investigate this topic. All donors had ADCC responses against 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) and avian influenza A(H7N9) virus hemagglutinins (HAs) despite being seronegative for these viruses in standard hemagglutination inhibition and microneutralization serological assays. A(H1N1)pdm09 exposure did not boost ADCC responses specific for H7 HA antigens. H7 HA ADCC responses were variable longitudinally within donors, suggesting that these cross-reactive antibodies are unstable. We found no correlation between ADCC responses to the H7 HA and either influenza virus-specific immunoglobulin G1 concentration or age. |
Persistent Identifier | http://hdl.handle.net/10722/236525 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Valkenburg, SA | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Chan, KY | - |
dc.contributor.author | Leung, K | - |
dc.contributor.author | Wu, JT | - |
dc.contributor.author | Poon, LLM | - |
dc.date.accessioned | 2016-11-25T00:54:36Z | - |
dc.date.available | 2016-11-25T00:54:36Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Infectious Diseases, 2016, v. 214 n. 8, p. 1159-1163 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236525 | - |
dc.description.abstract | Cross-reactive influenza virus-specific antibody-dependent cellular cytotoxicity (ADCC)-activating antibodies are readily detected in healthy adults. However, little is known about the kinetics of these ADCC responses. We used retrospective serial blood samples from healthy donors to investigate this topic. All donors had ADCC responses against 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) and avian influenza A(H7N9) virus hemagglutinins (HAs) despite being seronegative for these viruses in standard hemagglutination inhibition and microneutralization serological assays. A(H1N1)pdm09 exposure did not boost ADCC responses specific for H7 HA antigens. H7 HA ADCC responses were variable longitudinally within donors, suggesting that these cross-reactive antibodies are unstable. We found no correlation between ADCC responses to the H7 HA and either influenza virus-specific immunoglobulin G1 concentration or age. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/ | - |
dc.relation.ispartof | Journal of Infectious Diseases | - |
dc.subject | Influenza | - |
dc.subject | Antibody | - |
dc.subject | ADCC | - |
dc.subject | NK cells | - |
dc.title | Preexisting Antibody-Dependent Cellular Cytotoxicity–Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure | - |
dc.type | Article | - |
dc.identifier.email | Valkenburg, SA: sophiev@hku.hk | - |
dc.identifier.email | Chan, KY: ichan2@hku.hk | - |
dc.identifier.email | Leung, K: ksmleung@hku.hk | - |
dc.identifier.email | Wu, JT: joewu@hku.hk | - |
dc.identifier.email | Poon, LLM: llmpoon@hkucc.hku.hk | - |
dc.identifier.authority | Valkenburg, SA=rp02141 | - |
dc.identifier.authority | Leung, K=rp02563 | - |
dc.identifier.authority | Wu, JT=rp00517 | - |
dc.identifier.authority | Poon, LLM=rp00484 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/infdis/jiw346 | - |
dc.identifier.pmid | 27493238 | - |
dc.identifier.pmcid | PMC5034955 | - |
dc.identifier.scopus | eid_2-s2.0-84990909246 | - |
dc.identifier.hkuros | 270633 | - |
dc.identifier.hkuros | 287717 | - |
dc.identifier.volume | 214 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1159 | - |
dc.identifier.epage | 1163 | - |
dc.identifier.isi | WOS:000386147200008 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-1899 | - |