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- Publisher Website: 10.1016/0006-8993(94)90865-6
- Scopus: eid_2-s2.0-0027930791
- PMID: 7820683
- WOS: WOS:A1994PJ13000010
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Article: Selective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex
Title | Selective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex |
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Authors | |
Keywords | Baclofen |
Issue Date | 1994 |
Citation | Brain Research, 1994, v. 659, n. 1-2, p. 75-81 How to Cite? |
Abstract | The GABAB agonist baclofen has been shown to suppress synaptic transmission in subregions of the hippocampus and in the piriform (olfactory) cortex. Here we report a laminar selectivity of suppression of synaptic potentials in the olfactory cortex. In brain slice preparations, baclofen suppresses extracellularly recorded field potentials at the intrinsic fiber synapses proximal to the superficial pyramidal cell bodies (layer Ib) while leaving the af ferent fiber synaptic potentials recorded at the distal dendrites (layer Ia) little affected. This dose-dependent selective suppression of intrinsic fiber synaptic transmission is also correlated with an increase of paired-pulse facilitation. These results suggest that afferent and intrinsic synaptic inputs may be differentially modulated by the activation of GABAB receptors and that this selective suppression is at least partially mediated via a presynaptic mechanism. © 1994. |
Persistent Identifier | http://hdl.handle.net/10722/228000 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tang, Akaysha C. | - |
dc.contributor.author | Hasselmo, Michael E. | - |
dc.date.accessioned | 2016-08-01T06:44:56Z | - |
dc.date.available | 2016-08-01T06:44:56Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Brain Research, 1994, v. 659, n. 1-2, p. 75-81 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | http://hdl.handle.net/10722/228000 | - |
dc.description.abstract | The GABAB agonist baclofen has been shown to suppress synaptic transmission in subregions of the hippocampus and in the piriform (olfactory) cortex. Here we report a laminar selectivity of suppression of synaptic potentials in the olfactory cortex. In brain slice preparations, baclofen suppresses extracellularly recorded field potentials at the intrinsic fiber synapses proximal to the superficial pyramidal cell bodies (layer Ib) while leaving the af ferent fiber synaptic potentials recorded at the distal dendrites (layer Ia) little affected. This dose-dependent selective suppression of intrinsic fiber synaptic transmission is also correlated with an increase of paired-pulse facilitation. These results suggest that afferent and intrinsic synaptic inputs may be differentially modulated by the activation of GABAB receptors and that this selective suppression is at least partially mediated via a presynaptic mechanism. © 1994. | - |
dc.language | eng | - |
dc.relation.ispartof | Brain Research | - |
dc.subject | Baclofen | - |
dc.title | Selective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0006-8993(94)90865-6 | - |
dc.identifier.pmid | 7820683 | - |
dc.identifier.scopus | eid_2-s2.0-0027930791 | - |
dc.identifier.volume | 659 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 75 | - |
dc.identifier.epage | 81 | - |
dc.identifier.isi | WOS:A1994PJ13000010 | - |
dc.identifier.issnl | 0006-8993 | - |