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Article: IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling

TitleIKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling
Authors
KeywordsIKBB
Tumor suppressor
Tumor microenvironment
NF‐κB/Akt/GSK‐3β signalling pathway
Angiogenesis
Issue Date2016
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal of Cancer, 2016, v. 138 n. 1, p. 160-170 How to Cite?
AbstractTumor suppressor genes (TSGs) play a prominent role in cancer and are important in the development of nasopharyngeal carcinoma (NPC), which is endemic in Southern China as well as Southeast Asia. Apart from TSGs, aberrant signalling pathways are also commonly associated with tumor progression. Unsurprisingly, the NF‐κB pathway is frequently associated with angiogenesis and promoting tumor growth and development. Functional complementation studies using microcell‐mediated chromosome transfer helped to identify IKBB as a putative TSG in NPC. IKBB, an inhibitor of NF‐κB, has recently been shown to be inversely associated with tumor growth and metastasis via inactivation of the NF‐κB pathway, but its suppressive role is still only poorly understood. This study takes the lead in revealing the suppressive role of IKBB in NPC. IKBB is silenced in the majority of NPC tumor tissues in all stages. Its suppressive role is substantiated by perturbation in tumor formation, cell migration and angiogenesis. Interestingly, IKBB not only affects the ‘seed’, but also influences the ‘soil’ by downregulating the transcriptional level of proangiogenic factors Rantes, Upar, IL6, and IL8. For the first time, our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF‐κB signalling pathway, which is likely mediated by crosstalk with the Akt/Gsk3β signalling pathway.
Persistent Identifierhttp://hdl.handle.net/10722/227217
ISSN
2019 Impact Factor: 5.145
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPhoon, YP-
dc.contributor.authorCheung, AKL-
dc.contributor.authorCheung, FMF-
dc.contributor.authorChan, KF-
dc.contributor.authorWong, S-
dc.contributor.authorWong, BWY-
dc.contributor.authorTung, SY-
dc.contributor.authorYau, CC-
dc.contributor.authorNg, WT-
dc.contributor.authorLung, ML-
dc.date.accessioned2016-07-18T09:09:08Z-
dc.date.available2016-07-18T09:09:08Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Cancer, 2016, v. 138 n. 1, p. 160-170-
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/227217-
dc.description.abstractTumor suppressor genes (TSGs) play a prominent role in cancer and are important in the development of nasopharyngeal carcinoma (NPC), which is endemic in Southern China as well as Southeast Asia. Apart from TSGs, aberrant signalling pathways are also commonly associated with tumor progression. Unsurprisingly, the NF‐κB pathway is frequently associated with angiogenesis and promoting tumor growth and development. Functional complementation studies using microcell‐mediated chromosome transfer helped to identify IKBB as a putative TSG in NPC. IKBB, an inhibitor of NF‐κB, has recently been shown to be inversely associated with tumor growth and metastasis via inactivation of the NF‐κB pathway, but its suppressive role is still only poorly understood. This study takes the lead in revealing the suppressive role of IKBB in NPC. IKBB is silenced in the majority of NPC tumor tissues in all stages. Its suppressive role is substantiated by perturbation in tumor formation, cell migration and angiogenesis. Interestingly, IKBB not only affects the ‘seed’, but also influences the ‘soil’ by downregulating the transcriptional level of proangiogenic factors Rantes, Upar, IL6, and IL8. For the first time, our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF‐κB signalling pathway, which is likely mediated by crosstalk with the Akt/Gsk3β signalling pathway.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home-
dc.relation.ispartofInternational Journal of Cancer-
dc.subjectIKBB-
dc.subjectTumor suppressor-
dc.subjectTumor microenvironment-
dc.subjectNF‐κB/Akt/GSK‐3β signalling pathway-
dc.subjectAngiogenesis-
dc.titleIKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling-
dc.typeArticle-
dc.identifier.emailCheung, AKL: arthurhk@hku.hk-
dc.identifier.emailWong, BWY: bonniewongwy@hku.hk-
dc.identifier.emailNg, WT: ngwt1@hkucc.hku.hk-
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.authorityCheung, AKL=rp01769-
dc.identifier.authorityNg, WT=rp02671-
dc.identifier.authorityLung, ML=rp00300-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ijc.29702-
dc.identifier.pmid26227166-
dc.identifier.scopuseid_2-s2.0-84944275295-
dc.identifier.hkuros259643-
dc.identifier.volume138-
dc.identifier.issue1-
dc.identifier.spage160-
dc.identifier.epage170-
dc.identifier.isiWOS:000363203600020-
dc.publisher.placeUnited States-

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