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Conference Paper: New lights in light's criteria
Title | New lights in light's criteria |
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Authors | |
Issue Date | 2015 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp |
Citation | The 39th Annual Scientific Meeting of the Australasian Division of the International Academy of Pathology, Brisbane, Australia, 30 May-1 June 2014. In Pathology, 2015, v. 47 suppl. 1, p. S83 How to Cite? |
Abstract | AIMS: Nuclear magnetic resonance (NMR) spectroscopy-based metabolome-wide association studies (MWAS) has been increasingly used in advanced laboratory medicine and biomarker discovery. Here, we will apply NMR-based MWAS to develop new diagnostic test for exudative and transudative pleural effusions (PE) with improved accuracy. METHODS: PE will be classified into exudates and transudates according to the etiology and analyzed using 1H-NMR spectroscopy (600MHz). Biomarkers will be determined using MWAS using Receiver Operating Characteristic Curve Explorer and Tester (ROCCET) and filtered using a metabolome-wide significance level (MWSL) at p-value < 4×10−6. RESULTS: There were 50 exudates and 17 transudates. Using MWAS, lipoprotein was determined to be the best biomarker that differentiated exudates from transudates (p-value: 1.01×10−10) with an area-under-ROC curve of 0.96 (95% CI: 0.89–0.99), sensitivity of 98% and specificity of 88%. The diagnostic performance is superior to the current standard, Light’s criteria which showed a specificity of 65% despite the same sensitivity at 98%. DISCUSSION: The high level of lipoproteins in exudates is related to the larger capillary pore-size secondary to inflammation. In contrast, without inflammation, the capillary pore-size remains intact in transudates. We envisage NMR-based lipoprotein profiling will be a powerful tool for pleural capillary pore-size estimation and will become a new standard. (C) 2015 Royal College of Pathologists of Australasia |
Description | This journal suppl. entitled: Australasian Division of the International Academy of Pathology Abstracts 39th Annual Scientific Meeting 2014 |
Persistent Identifier | http://hdl.handle.net/10722/225416 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 0.919 |
DC Field | Value | Language |
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dc.contributor.author | Law, CY | - |
dc.contributor.author | Lam, CW | - |
dc.date.accessioned | 2016-05-12T04:33:58Z | - |
dc.date.available | 2016-05-12T04:33:58Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 39th Annual Scientific Meeting of the Australasian Division of the International Academy of Pathology, Brisbane, Australia, 30 May-1 June 2014. In Pathology, 2015, v. 47 suppl. 1, p. S83 | - |
dc.identifier.issn | 0031-3025 | - |
dc.identifier.uri | http://hdl.handle.net/10722/225416 | - |
dc.description | This journal suppl. entitled: Australasian Division of the International Academy of Pathology Abstracts 39th Annual Scientific Meeting 2014 | - |
dc.description.abstract | AIMS: Nuclear magnetic resonance (NMR) spectroscopy-based metabolome-wide association studies (MWAS) has been increasingly used in advanced laboratory medicine and biomarker discovery. Here, we will apply NMR-based MWAS to develop new diagnostic test for exudative and transudative pleural effusions (PE) with improved accuracy. METHODS: PE will be classified into exudates and transudates according to the etiology and analyzed using 1H-NMR spectroscopy (600MHz). Biomarkers will be determined using MWAS using Receiver Operating Characteristic Curve Explorer and Tester (ROCCET) and filtered using a metabolome-wide significance level (MWSL) at p-value < 4×10−6. RESULTS: There were 50 exudates and 17 transudates. Using MWAS, lipoprotein was determined to be the best biomarker that differentiated exudates from transudates (p-value: 1.01×10−10) with an area-under-ROC curve of 0.96 (95% CI: 0.89–0.99), sensitivity of 98% and specificity of 88%. The diagnostic performance is superior to the current standard, Light’s criteria which showed a specificity of 65% despite the same sensitivity at 98%. DISCUSSION: The high level of lipoproteins in exudates is related to the larger capillary pore-size secondary to inflammation. In contrast, without inflammation, the capillary pore-size remains intact in transudates. We envisage NMR-based lipoprotein profiling will be a powerful tool for pleural capillary pore-size estimation and will become a new standard. (C) 2015 Royal College of Pathologists of Australasia | - |
dc.language | eng | - |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp | - |
dc.relation.ispartof | Pathology | - |
dc.rights | Pathology. Copyright © Informa Healthcare. | - |
dc.title | New lights in light's criteria | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Law, CY: ericlaw@hku.hk | - |
dc.identifier.email | Lam, CW: ching-wanlam@pathology.hku.hk | - |
dc.identifier.authority | Law, CY=rp01586 | - |
dc.identifier.authority | Lam, CW=rp00260 | - |
dc.identifier.doi | 10.1097/01.PAT.0000461561.92836.8b | - |
dc.identifier.volume | 47 | - |
dc.identifier.issue | suppl. 1 | - |
dc.identifier.spage | S83 | - |
dc.identifier.epage | S83 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0031-3025 | - |