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Conference Paper: Assessment of extracellular matrix degradation in intervertebral disc degeneration by diffusion weighted MRS and chemical exchange saturation transfer
| Title | Assessment of extracellular matrix degradation in intervertebral disc degeneration by diffusion weighted MRS and chemical exchange saturation transfer |
|---|---|
| Authors | |
| Issue Date | 2015 |
| Citation | The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) and SMRT 24th Annual Meeting, Toronto, ON., Canada, 30 May-5 June 2015, no. 0315 How to Cite? |
| Abstract | This study compared the capability of diffusion weighted MRS (DW-MRS) and chemical exchange saturation transfer (CEST) methods in detecting and characterizing the ECM degradation during the early stage of IVDD in an ex vivo model. The apparent diffusion coefficient (ADC) of glycosaminoglycan (GAG) increased drastically immediately after papain injection, while the GAG concentration measured by both MRS and CEST method shared a similar but slow decreasing trend which happened later than the GAG ADC increase. The GAG ADC value, which is free from the influence of the GAG concentration, is an important potential marker for detecting the onset of the ECM degradation in IVDD. |
| Description | Summa Cum Laude Merit Award Scientific Session: Translations MR Imaging of Musculoskeletal Physiology: no. 0315 |
| Persistent Identifier | http://hdl.handle.net/10722/220307 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wang, AM | - |
| dc.contributor.author | Tsang, A | - |
| dc.contributor.author | Wu, EX | - |
| dc.date.accessioned | 2015-10-16T06:37:03Z | - |
| dc.date.available | 2015-10-16T06:37:03Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) and SMRT 24th Annual Meeting, Toronto, ON., Canada, 30 May-5 June 2015, no. 0315 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/220307 | - |
| dc.description | Summa Cum Laude Merit Award | - |
| dc.description | Scientific Session: Translations MR Imaging of Musculoskeletal Physiology: no. 0315 | - |
| dc.description.abstract | This study compared the capability of diffusion weighted MRS (DW-MRS) and chemical exchange saturation transfer (CEST) methods in detecting and characterizing the ECM degradation during the early stage of IVDD in an ex vivo model. The apparent diffusion coefficient (ADC) of glycosaminoglycan (GAG) increased drastically immediately after papain injection, while the GAG concentration measured by both MRS and CEST method shared a similar but slow decreasing trend which happened later than the GAG ADC increase. The GAG ADC value, which is free from the influence of the GAG concentration, is an important potential marker for detecting the onset of the ECM degradation in IVDD. | - |
| dc.language | eng | - |
| dc.relation.ispartof | ISMRM 23rd Annual Meeting & Exhibition cum SMRT 24th Annual Meeting Proceedings | - |
| dc.title | Assessment of extracellular matrix degradation in intervertebral disc degeneration by diffusion weighted MRS and chemical exchange saturation transfer | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
| dc.identifier.authority | Wu, EX=rp00193 | - |
| dc.identifier.hkuros | 255286 | - |
| dc.identifier.hkuros | 255334 | - |