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Conference Paper: Intrahippocampal and hippocampal-cortical interactions driven by frequency specific optogenetic stimulation
Title | Intrahippocampal and hippocampal-cortical interactions driven by frequency specific optogenetic stimulation |
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Authors | |
Issue Date | 2015 |
Citation | The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) and SMRT 24th Annual Meeting, Toronto, ON., Canada, 30 May-5 June 2015, no. 0133 How to Cite? |
Abstract | Previous studies suggested that the intrahippocampal interactions may be governed by gamma oscillations, while hippocampal-cortical interactions might be directed by low frequency oscillation and/or sharp wave-ripple. However, exactly how different frequency contributes to large-scale intrahippocampal and hippocampal-cortical interactions remains largely unknown. In this study, optogenetic functional MRI was applied to investigate the frequency-dependent hippocampal network activity. Large-scale hippocampal and cortical activations were found during 40Hz and 1Hz stimulation, respectively. This is also the first study demonstrating large-scale and widespread hippocampal-cortical activity by driving CaMKIIa-positive cells in the dorsal hippocampus. This widespread hippocampal-cortical activity suggests that the generation of low frequency oscillation in the dorsal hippocampus can modulate cortical activity. |
Description | Summa Cum Laude Merit Award Scientific Session: fMRI Applications, Including Optogenetics: no. 0133 |
Persistent Identifier | http://hdl.handle.net/10722/220306 |
DC Field | Value | Language |
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dc.contributor.author | Chan, RW | - |
dc.contributor.author | Cheng, JS | - |
dc.contributor.author | Cheng, JS | - |
dc.contributor.author | Gao, PP | - |
dc.contributor.author | Fan, SJ | - |
dc.contributor.author | Tsia, KK | - |
dc.contributor.author | Wu, EX | - |
dc.date.accessioned | 2015-10-16T06:36:59Z | - |
dc.date.available | 2015-10-16T06:36:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) and SMRT 24th Annual Meeting, Toronto, ON., Canada, 30 May-5 June 2015, no. 0133 | - |
dc.identifier.uri | http://hdl.handle.net/10722/220306 | - |
dc.description | Summa Cum Laude Merit Award | - |
dc.description | Scientific Session: fMRI Applications, Including Optogenetics: no. 0133 | - |
dc.description.abstract | Previous studies suggested that the intrahippocampal interactions may be governed by gamma oscillations, while hippocampal-cortical interactions might be directed by low frequency oscillation and/or sharp wave-ripple. However, exactly how different frequency contributes to large-scale intrahippocampal and hippocampal-cortical interactions remains largely unknown. In this study, optogenetic functional MRI was applied to investigate the frequency-dependent hippocampal network activity. Large-scale hippocampal and cortical activations were found during 40Hz and 1Hz stimulation, respectively. This is also the first study demonstrating large-scale and widespread hippocampal-cortical activity by driving CaMKIIa-positive cells in the dorsal hippocampus. This widespread hippocampal-cortical activity suggests that the generation of low frequency oscillation in the dorsal hippocampus can modulate cortical activity. | - |
dc.language | eng | - |
dc.relation.ispartof | ISMRM 23rd Annual Meeting & Exhibition cum SMRT 24th Annual Meeting Proceedings | - |
dc.title | Intrahippocampal and hippocampal-cortical interactions driven by frequency specific optogenetic stimulation | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, RW: chanrw@hku.hk | - |
dc.identifier.email | Fan, SJ: fanshj08@hkucc.hku.hk | - |
dc.identifier.email | Tsia, KK: tsia@hku.hk | - |
dc.identifier.email | Wu, EX: ewu1@hkucc.hku.hk | - |
dc.identifier.authority | Tsia, KK=rp01389 | - |
dc.identifier.authority | Wu, EX=rp00193 | - |
dc.identifier.hkuros | 255279 | - |