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Article: Central pontine myelinolysis: report of two occurrences after cisplatin-containing chemotherapy for nasopharyngeal carcinoma

TitleCentral pontine myelinolysis: report of two occurrences after cisplatin-containing chemotherapy for nasopharyngeal carcinoma
Authors
Yau, TKYiu, HYLee, WMA
KeywordsAdult
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Carcinoma/*drug therapy
Cisplatin/administration & dosage
Female
Fluorouracil/administration & dosage
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Myelinolysis, Central Pontine/*chemically induced
Nasopharyngeal Neoplasms/*drug therapy
Issue Date1993
Citation
Clinical oncology (R Coll Radiol), 1993, v. 5 n. 6, p. 395-396 How to Cite?
DOI: http://dx.doi.org/10.1016/S0936-6555(05)80096-2
AbstractWe report two patients with the classical clinical syndrome of central pontine myelinolysis following cisplatin based chemotherapy for nasopharyngeal carcinoma. The diagnosis was supported by typical features on magnetic resonance imaging. Rapid correction of hyponatraemia was the most likely cause. A short course of corticosteroids was tried in both patients. Although one patient experienced almost complete recovery, the other still suffered from residual motor deficit. The importance of careful monitoring of the rate of electrolyte correction is emphasized.
Persistent Identifierhttp://hdl.handle.net/10722/220036
ISSN
0936-6555
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.907

 

DC FieldValueLanguage
dc.contributor.authorYau, TK-
dc.contributor.authorYiu, HY-
dc.contributor.authorLee, WMA-
dc.date.accessioned2015-10-16T06:16:36Z-
dc.date.available2015-10-16T06:16:36Z-
dc.date.issued1993-
dc.identifier.citationClinical oncology (R Coll Radiol), 1993, v. 5 n. 6, p. 395-396-
dc.identifier.issn0936-6555-
dc.identifier.urihttp://hdl.handle.net/10722/220036-
dc.description.abstractWe report two patients with the classical clinical syndrome of central pontine myelinolysis following cisplatin based chemotherapy for nasopharyngeal carcinoma. The diagnosis was supported by typical features on magnetic resonance imaging. Rapid correction of hyponatraemia was the most likely cause. A short course of corticosteroids was tried in both patients. Although one patient experienced almost complete recovery, the other still suffered from residual motor deficit. The importance of careful monitoring of the rate of electrolyte correction is emphasized.-
dc.languageeng-
dc.relation.ispartofClin Oncol (R Coll Radiol)-
dc.subjectAdult-
dc.subjectAntineoplastic Combined Chemotherapy Protocols/*adverse effects-
dc.subjectCarcinoma/*drug therapy-
dc.subjectCisplatin/administration & dosage-
dc.subjectFemale-
dc.subjectFluorouracil/administration & dosage-
dc.subjectHumans-
dc.subjectMagnetic Resonance Imaging-
dc.subjectMale-
dc.subjectMiddle Aged-
dc.subjectMyelinolysis, Central Pontine/*chemically induced-
dc.subjectNasopharyngeal Neoplasms/*drug therapy-
dc.titleCentral pontine myelinolysis: report of two occurrences after cisplatin-containing chemotherapy for nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailLee, WMA: awmlee@hkucc.hku.hk-
dc.identifier.authorityLee, WMA=rp02056-
dc.identifier.doi10.1016/S0936-6555(05)80096-2-
dc.identifier.pmid8305365-
dc.identifier.scopuseid_2-s2.0-0027731847-
dc.identifier.hkuros266414-
dc.identifier.volume5-
dc.identifier.issue6-
dc.identifier.spage395-
dc.identifier.epage396-
dc.identifier.issnl0936-6555-

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