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- Publisher Website: 10.1161/STROKEAHA.114.005023
- Scopus: eid_2-s2.0-84906807987
- PMID: 25028448
- WOS: WOS:000341491500032
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Article: Risk score to predict hospital-acquired pneumonia after spontaneous intracerebral hemorrhage
Title | Risk score to predict hospital-acquired pneumonia after spontaneous intracerebral hemorrhage |
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Authors | |
Keywords | forecasting cerebral hemorrhage pneumonia |
Issue Date | 2014 |
Citation | Stroke, 2014, v. 45, n. 9, p. 2620-2628 How to Cite? |
Abstract | BACKGROUND AND PURPOSE-: We aimed to develop a risk score (intracerebral hemorrhage-associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated pneumonia (SAP) after ICH. METHODS-: The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Variables routinely collected at presentation were used for predicting SAP after ICH. For testing the added value of hematoma volume measure, we separately developed 2 models with (ICH-APS-B) and without (ICH-APS-A) hematoma volume included. Multivariable logistic regression was performed to identify independent predictors. The area under the receiver operating characteristic curve (AUROC), Hosmer-Lemeshow goodness-of-fit test, and integrated discrimination index were used to assess model discrimination, calibration, and reclassification, respectively. RESULTS-: The SAP was 16.4% and 17.7% in the overall derivation (n=2998) and validation (n=2000) cohorts, respectively. A 23-point ICH-APS-A was developed based on a set of predictors and showed good discrimination in the overall derivation (AUROC, 0.75; 95% confidence interval, 0.72-0.77) and validation (AUROC, 0.76; 95% confidence interval, 0.71-0.79) cohorts. The ICH-APS-A was more sensitive for patients with length of stay >48 hours (AUROC, 0.78; 95% confidence interval, 0.75-0.81) than those with length of stay <48 hours (AUROC, 0.64; 95% confidence interval, 0.55-0.73). The ICH-APS-A was well calibrated (Hosmer-Lemeshow test) in the derivation (P=0.20) and validation (P=0.66) cohorts. Similarly, a 26-point ICH-APS-B was established. The ICH-APS-A and ICH-APS-B were not significantly different in discrimination and reclassification for SAP after ICH. CONCLUSION-: The ICH-APSs are valid risk scores for predicting SAP after ICH, especially for patients with length of stay >48 hours. © 2014 American Heart Association, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/219759 |
ISSN | 2023 Impact Factor: 7.8 2023 SCImago Journal Rankings: 2.450 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ji, Ruijun | - |
dc.contributor.author | Shen, Haipeng | - |
dc.contributor.author | Pan, Yuesong | - |
dc.contributor.author | Du, Wanliang | - |
dc.contributor.author | Wang, Penglian | - |
dc.contributor.author | Liu, Gaifen | - |
dc.contributor.author | Wang, Yilong | - |
dc.contributor.author | Li, Hao | - |
dc.contributor.author | Zhao, Xingquan | - |
dc.contributor.author | Wang, Yongjun | - |
dc.date.accessioned | 2015-09-23T02:57:54Z | - |
dc.date.available | 2015-09-23T02:57:54Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Stroke, 2014, v. 45, n. 9, p. 2620-2628 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219759 | - |
dc.description.abstract | BACKGROUND AND PURPOSE-: We aimed to develop a risk score (intracerebral hemorrhage-associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated pneumonia (SAP) after ICH. METHODS-: The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Variables routinely collected at presentation were used for predicting SAP after ICH. For testing the added value of hematoma volume measure, we separately developed 2 models with (ICH-APS-B) and without (ICH-APS-A) hematoma volume included. Multivariable logistic regression was performed to identify independent predictors. The area under the receiver operating characteristic curve (AUROC), Hosmer-Lemeshow goodness-of-fit test, and integrated discrimination index were used to assess model discrimination, calibration, and reclassification, respectively. RESULTS-: The SAP was 16.4% and 17.7% in the overall derivation (n=2998) and validation (n=2000) cohorts, respectively. A 23-point ICH-APS-A was developed based on a set of predictors and showed good discrimination in the overall derivation (AUROC, 0.75; 95% confidence interval, 0.72-0.77) and validation (AUROC, 0.76; 95% confidence interval, 0.71-0.79) cohorts. The ICH-APS-A was more sensitive for patients with length of stay >48 hours (AUROC, 0.78; 95% confidence interval, 0.75-0.81) than those with length of stay <48 hours (AUROC, 0.64; 95% confidence interval, 0.55-0.73). The ICH-APS-A was well calibrated (Hosmer-Lemeshow test) in the derivation (P=0.20) and validation (P=0.66) cohorts. Similarly, a 26-point ICH-APS-B was established. The ICH-APS-A and ICH-APS-B were not significantly different in discrimination and reclassification for SAP after ICH. CONCLUSION-: The ICH-APSs are valid risk scores for predicting SAP after ICH, especially for patients with length of stay >48 hours. © 2014 American Heart Association, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Stroke | - |
dc.subject | forecasting | - |
dc.subject | cerebral hemorrhage | - |
dc.subject | pneumonia | - |
dc.title | Risk score to predict hospital-acquired pneumonia after spontaneous intracerebral hemorrhage | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1161/STROKEAHA.114.005023 | - |
dc.identifier.pmid | 25028448 | - |
dc.identifier.scopus | eid_2-s2.0-84906807987 | - |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 2620 | - |
dc.identifier.epage | 2628 | - |
dc.identifier.eissn | 1524-4628 | - |
dc.identifier.isi | WOS:000341491500032 | - |
dc.identifier.issnl | 0039-2499 | - |