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- Publisher Website: 10.1016/0360-3016(94)90317-4
- Scopus: eid_2-s2.0-0028170952
- PMID: 7961019
- WOS: WOS:A1994PT59800014
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Article: T1 nasopharyngeal carcinoma: The effect of waiting time on tumor control
Title | T1 nasopharyngeal carcinoma: The effect of waiting time on tumor control |
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Authors | |
Keywords | Nasopharyngeal carcinoma Probability of tumor control Unperturbed tumor growth Waiting time |
Issue Date | 1994 |
Citation | International Journal of Radiation Oncology - Biology - Physics, 1994, v. 30, n. 5, p. 1111-1117 How to Cite? |
Abstract | Purpose: To study the effect of unperturbed tumor growth on the control of nasopharyngeal carcinoma. Methods and Materials: This is a retrospective analysis of 290 patients with T1Na0-3M0 disease (Ho's classification) treated by the same technique and dose schedule to the nasopharyngeal region. The median interval from diagnosis to commencement of irradiation was 26 days (range: 8-68 days). Cox proportional hazards analyses were performed to study the independent effect of waiting time on the probability of failure at various sites. Actuarial failure-free survival of patients with delay < 22 days, 22-28 days and > 28 days were also compared to illustrate the clinical observation. Results: Both tests showed that waiting time had no significant impact on local failure: The N-stage stratified hazard ratio was 0.985 per day, and the 10-year local failure-free survival for the three groups was 76%, 80%, and 82%, respectively. A similar result was obtained for nodal control in patients with our scheduled neck irradiation. Although the p value of all tests failed to reach statistical significance, the N-stage stratified hazard ratio for distant failure was 1.020 per day, and the corresponding metastasis-free survival in patients with N2-3 disease was 70%, 65%, and 52%, respectively. For node-negative patients without elective neck irradiation, the hazard ratio was 1.019 per day, with the corresponding regional failure-free rates at 57%, 62%, and 33%, respectively. Conclusion: Delay in initiation of treatment to the primary target (within the range observed) did not affect the control rate at irradiated sites, but there was a trend (though statistically insignificant) towards increase in failures at untreated sites that were clinically too serious to be ignored. © 1994. |
Persistent Identifier | http://hdl.handle.net/10722/213854 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 1.992 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, Anne W M | - |
dc.contributor.author | Chan, David K K | - |
dc.contributor.author | Fowler, Jack F. | - |
dc.contributor.author | Pooh, Y. F. | - |
dc.contributor.author | Law, Stephen C K | - |
dc.contributor.author | Foo, William | - |
dc.contributor.author | O, S. K. | - |
dc.contributor.author | Tung, Stewart Y. | - |
dc.contributor.author | Cheung, Fred K. | - |
dc.contributor.author | Ho, John H C | - |
dc.contributor.author | Chappell, Rick | - |
dc.date.accessioned | 2015-08-19T13:40:58Z | - |
dc.date.available | 2015-08-19T13:40:58Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | International Journal of Radiation Oncology - Biology - Physics, 1994, v. 30, n. 5, p. 1111-1117 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | http://hdl.handle.net/10722/213854 | - |
dc.description.abstract | Purpose: To study the effect of unperturbed tumor growth on the control of nasopharyngeal carcinoma. Methods and Materials: This is a retrospective analysis of 290 patients with T1Na0-3M0 disease (Ho's classification) treated by the same technique and dose schedule to the nasopharyngeal region. The median interval from diagnosis to commencement of irradiation was 26 days (range: 8-68 days). Cox proportional hazards analyses were performed to study the independent effect of waiting time on the probability of failure at various sites. Actuarial failure-free survival of patients with delay < 22 days, 22-28 days and > 28 days were also compared to illustrate the clinical observation. Results: Both tests showed that waiting time had no significant impact on local failure: The N-stage stratified hazard ratio was 0.985 per day, and the 10-year local failure-free survival for the three groups was 76%, 80%, and 82%, respectively. A similar result was obtained for nodal control in patients with our scheduled neck irradiation. Although the p value of all tests failed to reach statistical significance, the N-stage stratified hazard ratio for distant failure was 1.020 per day, and the corresponding metastasis-free survival in patients with N2-3 disease was 70%, 65%, and 52%, respectively. For node-negative patients without elective neck irradiation, the hazard ratio was 1.019 per day, with the corresponding regional failure-free rates at 57%, 62%, and 33%, respectively. Conclusion: Delay in initiation of treatment to the primary target (within the range observed) did not affect the control rate at irradiated sites, but there was a trend (though statistically insignificant) towards increase in failures at untreated sites that were clinically too serious to be ignored. © 1994. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Radiation Oncology - Biology - Physics | - |
dc.subject | Nasopharyngeal carcinoma | - |
dc.subject | Probability of tumor control | - |
dc.subject | Unperturbed tumor growth | - |
dc.subject | Waiting time | - |
dc.title | T1 nasopharyngeal carcinoma: The effect of waiting time on tumor control | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0360-3016(94)90317-4 | - |
dc.identifier.pmid | 7961019 | - |
dc.identifier.scopus | eid_2-s2.0-0028170952 | - |
dc.identifier.hkuros | 265836 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1111 | - |
dc.identifier.epage | 1117 | - |
dc.identifier.isi | WOS:A1994PT59800014 | - |
dc.identifier.issnl | 0360-3016 | - |