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- Publisher Website: 10.1016/0360-3016(89)90524-5
- Scopus: eid_2-s2.0-0024816501
- PMID: 2513290
- WOS: WOS:A1989CE80800007
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Article: Treatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation
Title | Treatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation |
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Authors | |
Keywords | Megavoltage radiation therapy Patterns of relapse No elective whole neck irradiation Nasopharyngeal carcinoma Prognostic factors Treatment complications Stage I (Ho's classification) |
Issue Date | 1989 |
Citation | International Journal of Radiation Oncology - Biology - Physics, 1989, v. 17, n. 6, p. 1183-1190 How to Cite? |
Abstract | This is a retrospective analysis of 196 patients with nasopharyngeal carcinoma Stage I (Ho's classification) treated by megavoltage radiation during 1980-1984. The primary target volume included all potential sites of local invasion and the first station lymph nodes at retropharyngeal spaces. Two different dose schedules were used, both gave a total tumor dose biologically equivalent to 65 Gy by conventional fractionation, and both achieved a 5-year actuarial local-recurrence-free survival of 88%. Elective neck irradiation was withheld in all except seven patients. The overall 7-year actuarial survival was 85%, but the relapse-free survival was only 62%. The patterns of relapse, prognostic factors, and treatment complications were analyzed. Eighteen patients (9%) recurred locally. Radical retreatment with radiation achieved complete remission in seven out of fifteen cases. Distant failure occurred in 17 patients (9%). Although 57 (30%) of the 189 patients without elective neck irradiation subsequently showed lymph node involvement, none of the seven regionally-treated patients relapsed. The successful regional salvage rate was 81% overall (46 out of 57 patients), but 90% (44 of 49) for those properly treated with whole neck irradiation. However, the 7-year actuarial survival was lower in patients with nodal relapse than those without (70% versus 87%) because of the associated higher incidence of hematogenous dissemination. The various aspects of treatment, the value of elective neck irradiation in particular, are discussed. © 1989. |
Persistent Identifier | http://hdl.handle.net/10722/213842 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 1.992 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, Anne W M | - |
dc.contributor.author | Sham, Jonathan S T | - |
dc.contributor.author | Poon, Y. F. | - |
dc.contributor.author | Ho, John H C | - |
dc.date.accessioned | 2015-08-19T13:40:55Z | - |
dc.date.available | 2015-08-19T13:40:55Z | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | International Journal of Radiation Oncology - Biology - Physics, 1989, v. 17, n. 6, p. 1183-1190 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | http://hdl.handle.net/10722/213842 | - |
dc.description.abstract | This is a retrospective analysis of 196 patients with nasopharyngeal carcinoma Stage I (Ho's classification) treated by megavoltage radiation during 1980-1984. The primary target volume included all potential sites of local invasion and the first station lymph nodes at retropharyngeal spaces. Two different dose schedules were used, both gave a total tumor dose biologically equivalent to 65 Gy by conventional fractionation, and both achieved a 5-year actuarial local-recurrence-free survival of 88%. Elective neck irradiation was withheld in all except seven patients. The overall 7-year actuarial survival was 85%, but the relapse-free survival was only 62%. The patterns of relapse, prognostic factors, and treatment complications were analyzed. Eighteen patients (9%) recurred locally. Radical retreatment with radiation achieved complete remission in seven out of fifteen cases. Distant failure occurred in 17 patients (9%). Although 57 (30%) of the 189 patients without elective neck irradiation subsequently showed lymph node involvement, none of the seven regionally-treated patients relapsed. The successful regional salvage rate was 81% overall (46 out of 57 patients), but 90% (44 of 49) for those properly treated with whole neck irradiation. However, the 7-year actuarial survival was lower in patients with nodal relapse than those without (70% versus 87%) because of the associated higher incidence of hematogenous dissemination. The various aspects of treatment, the value of elective neck irradiation in particular, are discussed. © 1989. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Radiation Oncology - Biology - Physics | - |
dc.subject | Megavoltage radiation therapy | - |
dc.subject | Patterns of relapse | - |
dc.subject | No elective whole neck irradiation | - |
dc.subject | Nasopharyngeal carcinoma | - |
dc.subject | Prognostic factors | - |
dc.subject | Treatment complications | - |
dc.subject | Stage I (Ho's classification) | - |
dc.title | Treatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0360-3016(89)90524-5 | - |
dc.identifier.pmid | 2513290 | - |
dc.identifier.scopus | eid_2-s2.0-0024816501 | - |
dc.identifier.hkuros | 265776 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1183 | - |
dc.identifier.epage | 1190 | - |
dc.identifier.isi | WOS:A1989CE80800007 | - |
dc.identifier.issnl | 0360-3016 | - |