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- Publisher Website: 10.2174/1381612811306010005
- Scopus: eid_2-s2.0-84873952954
- PMID: 22950507
- WOS: WOS:000311091700003
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Article: Nicotine and gastrointestinal disorders: Its role in ulceration and cancer development
Title | Nicotine and gastrointestinal disorders: Its role in ulceration and cancer development |
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Authors | |
Keywords | Colon cancer Adrenergic receptors Angiogenesis Cigarette smoke Crohn's disease EMT Gastric cancer Gastric ulceration miRNA nAChRs Nicotine NNK Ulcerative colitis |
Issue Date | 2013 |
Citation | Current Pharmaceutical Design, 2013, v. 19, n. 1, p. 5-10 How to Cite? |
Abstract | Cigarette smoke has always been the single most preventive cause of death in the world. In 2011, over 460,000 died from cigarette smoke-related diseases in US. The detrimental effects of cigarette smoke on human beings are due to the presence of many carcinogens and other components (e.g. nicotine and tar). Nicotine is now accepted as one of the major components responsible for gastrointestinal disorders. Cigarette smoking, nicotine and a nicotine-derived nitrosamine, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered as risk factors for gastrointestinal cancer, however, the underlying mechanism remains largely unknown. Previous studies reported that cigarette smoke and nicotine aggravated inflammation not only in the stomach, but also in the colon. The carcinogenic actions of cigarette smoke, nicotine and NNK on gastrointestinal cancers development have been widely studied. The strong association of cyclooxygenase-2 (COX-2) with gastrointestinal diseases has been extensively studied, however, due to the unresolved cardiovascular risk, it is of great importance to develop other new anti-cancer drugs for the treatment of cancers. This current review aims to provide an overview of the effects of cigarette smoke, nicotine and NNK on gastrointestinal inflammation, and also the carcinogenic properties in cancer development (tumor growth, angiogenesis and epithelial-mesenchymal transition). In addition, current studies on nicotinic acetylcholine receptors, adrenergic receptors and miRNAs in nicotine-related cancer pathogenesis are also highlighted. © 2013 Bentham Science Publishers. |
Persistent Identifier | http://hdl.handle.net/10722/207524 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.586 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chu, Kent Man | - |
dc.contributor.author | Cho, Chihin | - |
dc.contributor.author | Shin, Vivianyvonne | - |
dc.date.accessioned | 2014-12-31T01:01:49Z | - |
dc.date.available | 2014-12-31T01:01:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Current Pharmaceutical Design, 2013, v. 19, n. 1, p. 5-10 | - |
dc.identifier.issn | 1381-6128 | - |
dc.identifier.uri | http://hdl.handle.net/10722/207524 | - |
dc.description.abstract | Cigarette smoke has always been the single most preventive cause of death in the world. In 2011, over 460,000 died from cigarette smoke-related diseases in US. The detrimental effects of cigarette smoke on human beings are due to the presence of many carcinogens and other components (e.g. nicotine and tar). Nicotine is now accepted as one of the major components responsible for gastrointestinal disorders. Cigarette smoking, nicotine and a nicotine-derived nitrosamine, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered as risk factors for gastrointestinal cancer, however, the underlying mechanism remains largely unknown. Previous studies reported that cigarette smoke and nicotine aggravated inflammation not only in the stomach, but also in the colon. The carcinogenic actions of cigarette smoke, nicotine and NNK on gastrointestinal cancers development have been widely studied. The strong association of cyclooxygenase-2 (COX-2) with gastrointestinal diseases has been extensively studied, however, due to the unresolved cardiovascular risk, it is of great importance to develop other new anti-cancer drugs for the treatment of cancers. This current review aims to provide an overview of the effects of cigarette smoke, nicotine and NNK on gastrointestinal inflammation, and also the carcinogenic properties in cancer development (tumor growth, angiogenesis and epithelial-mesenchymal transition). In addition, current studies on nicotinic acetylcholine receptors, adrenergic receptors and miRNAs in nicotine-related cancer pathogenesis are also highlighted. © 2013 Bentham Science Publishers. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Pharmaceutical Design | - |
dc.subject | Colon cancer | - |
dc.subject | Adrenergic receptors | - |
dc.subject | Angiogenesis | - |
dc.subject | Cigarette smoke | - |
dc.subject | Crohn's disease | - |
dc.subject | EMT | - |
dc.subject | Gastric cancer | - |
dc.subject | Gastric ulceration | - |
dc.subject | miRNA | - |
dc.subject | nAChRs | - |
dc.subject | Nicotine | - |
dc.subject | NNK | - |
dc.subject | Ulcerative colitis | - |
dc.title | Nicotine and gastrointestinal disorders: Its role in ulceration and cancer development | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2174/1381612811306010005 | - |
dc.identifier.pmid | 22950507 | - |
dc.identifier.scopus | eid_2-s2.0-84873952954 | - |
dc.identifier.hkuros | 213027 | - |
dc.identifier.hkuros | 212898 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 5 | - |
dc.identifier.epage | 10 | - |
dc.identifier.eissn | 1873-4286 | - |
dc.identifier.isi | WOS:000311091700003 | - |
dc.identifier.issnl | 1381-6128 | - |