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Conference Paper: Extremely slow water diffusion in rodent brain as a intracellular biomarker for aging
| Title | Extremely slow water diffusion in rodent brain as a intracellular biomarker for aging |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Publisher | ISMRM-ESMRMB 2014. |
| Citation | The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. How to Cite? |
| Abstract | Extremely slow water diffusion at ultrahigh b values in brain is thought to be related to restricted water diffusion in the nerve fibers and transmembrane water flux. With diffusion-weighted MRS, this study demonstrated a decrease of slow water ADC and increase of its fraction with aging, and the gradual development of the slow-diffusion water pool during postnatal development. These results were potentially related to the degenerative changes in nerve fiber during aging and the development of axonal membranes and myelin sheath during early life, supporting slow water diffusion as an intracellular biomarker for assessing aging-related structural brain changes. |
| Description | Electronic Poster Session - Neuro 2: Normal Ageing Brain: no. 4689 |
| Persistent Identifier | http://hdl.handle.net/10722/204162 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Fan, S | en_US |
| dc.contributor.author | Cao, P | en_US |
| dc.contributor.author | Han, WA | en_US |
| dc.contributor.author | Wu, EX | en_US |
| dc.date.accessioned | 2014-09-19T20:07:37Z | - |
| dc.date.available | 2014-09-19T20:07:37Z | - |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/204162 | - |
| dc.description | Electronic Poster Session - Neuro 2: Normal Ageing Brain: no. 4689 | - |
| dc.description.abstract | Extremely slow water diffusion at ultrahigh b values in brain is thought to be related to restricted water diffusion in the nerve fibers and transmembrane water flux. With diffusion-weighted MRS, this study demonstrated a decrease of slow water ADC and increase of its fraction with aging, and the gradual development of the slow-diffusion water pool during postnatal development. These results were potentially related to the degenerative changes in nerve fiber during aging and the development of axonal membranes and myelin sheath during early life, supporting slow water diffusion as an intracellular biomarker for assessing aging-related structural brain changes. | - |
| dc.language | eng | en_US |
| dc.publisher | ISMRM-ESMRMB 2014. | - |
| dc.relation.ispartof | ISMRM-ESMRMB Annual Meeting 2014 | en_US |
| dc.title | Extremely slow water diffusion in rodent brain as a intracellular biomarker for aging | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Fan, S: fanshj08@hkucc.hku.hk | en_US |
| dc.identifier.email | Wu, EX: ewu1@hkucc.hku.hk | en_US |
| dc.identifier.authority | Wu, EX=rp00193 | en_US |
| dc.description.nature | link_to_OA_fulltext | - |
| dc.identifier.hkuros | 240642 | en_US |
| dc.publisher.place | Italy | en_US |