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Conference Paper: Asymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging

TitleAsymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging
Authors
Wong, TWLau, KSTang, YHHo, KYWong, KKYShum, HCTsia, KKM
KeywordsBiophotonics
Cell imaging
High-speed microfluidic
High-throughput
Imaging flow cytometry
Time-stretch imaging
Ultrafast frame rate
Issue Date2014
PublisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml?WT.svl=mddp2
Citation
Conference 8947 - Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, San Francisco, California, USA, 3-6 February 2014. In Proceedings of SPIE - International Society for Optical Engineering, 2014, v. 8947, p. article no. 89471D How to Cite?
DOI: http://dx.doi.org/10.1117/12.2038952
AbstractHigh-throughput cellular imaging is acclaimed as captivating yet challenging in biomedical diagnostics. We have demonstrated a new imaging modality, asymmetric-detection time-stretch optical microscopy (ATOM), by incorporating a simple detection scheme which is a further advancement in time-stretch microscopy - a viable solution to achieve high-speed and high-throughput cellular imaging. Through the asymmetric-detection scheme in ATOM, the time-stretch image contrast is enhanced through accessing to the phase-gradient information. With the operation in the 1 μm wavelength range, we demonstrate high-resolution and high-contrast cellular imaging in ultrafast microfluidic flow (up to 10 m/s) by ATOM - achieving an imaging throughput equivalent to 100,000 cells/sec. © 2014 SPIE.
Persistent Identifierhttp://hdl.handle.net/10722/204010
ISBN
9780819498601
ISSN
0277-786X
2020 SCImago Journal Rankings: 0.192
ISI Accession Number ID
WOS:000336037200029

 

DC FieldValueLanguage
dc.contributor.authorWong, TWen_US
dc.contributor.authorLau, KSen_US
dc.contributor.authorTang, YHen_US
dc.contributor.authorHo, KYen_US
dc.contributor.authorWong, KKYen_US
dc.contributor.authorShum, HCen_US
dc.contributor.authorTsia, KKMen_US
dc.date.accessioned2014-09-19T20:01:37Z-
dc.date.available2014-09-19T20:01:37Z-
dc.date.issued2014en_US
dc.identifier.citationConference 8947 - Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, San Francisco, California, USA, 3-6 February 2014. In Proceedings of SPIE - International Society for Optical Engineering, 2014, v. 8947, p. article no. 89471Den_US
dc.identifier.isbn9780819498601-
dc.identifier.issn0277-786X-
dc.identifier.urihttp://hdl.handle.net/10722/204010-
dc.description.abstractHigh-throughput cellular imaging is acclaimed as captivating yet challenging in biomedical diagnostics. We have demonstrated a new imaging modality, asymmetric-detection time-stretch optical microscopy (ATOM), by incorporating a simple detection scheme which is a further advancement in time-stretch microscopy - a viable solution to achieve high-speed and high-throughput cellular imaging. Through the asymmetric-detection scheme in ATOM, the time-stretch image contrast is enhanced through accessing to the phase-gradient information. With the operation in the 1 μm wavelength range, we demonstrate high-resolution and high-contrast cellular imaging in ultrafast microfluidic flow (up to 10 m/s) by ATOM - achieving an imaging throughput equivalent to 100,000 cells/sec. © 2014 SPIE.-
dc.languageengen_US
dc.publisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml?WT.svl=mddp2-
dc.relation.ispartofProceedings of SPIE - International Society for Optical Engineeringen_US
dc.rightsCopyright 2014 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited. This article is available online at https://doi.org/10.1117/12.2038952-
dc.subjectBiophotonics-
dc.subjectCell imaging-
dc.subjectHigh-speed microfluidic-
dc.subjectHigh-throughput-
dc.subjectImaging flow cytometry-
dc.subjectTime-stretch imaging-
dc.subjectUltrafast frame rate-
dc.titleAsymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imagingen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, KKY: kywong04@hkucc.hku.hken_US
dc.identifier.emailShum, HC: ashum@hku.hken_US
dc.identifier.emailTsia, KKM: tsia@hku.hken_US
dc.identifier.authorityWong, KKY=rp00189en_US
dc.identifier.authorityShum, HC=rp01439en_US
dc.identifier.authorityTsia, KKM=rp01389en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1117/12.2038952-
dc.identifier.scopuseid_2-s2.0-84901771165-
dc.identifier.hkuros236209en_US
dc.identifier.volume8947-
dc.identifier.isiWOS:000336037200029-
dc.publisher.placeUnited States-
dc.identifier.issnl0277-786X-

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