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- Publisher Website: 10.1111/1469-0691.12739
- Scopus: eid_2-s2.0-84917675883
- WOS: WOS:000346337000043
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Article: Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B
Title | Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B |
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Authors | |
Keywords | HBV HBcrAg HBsAg HQ-HBsAg Serology |
Issue Date | 2014 |
Citation | Clinical Microbiology and Infection, 2014, v. 20 n. 11, p. 1173-1180 How to Cite? |
Abstract | Background: Changes in two novel HBV serologic markers, linearized hepatitis B surface antigen (HQ-HBsAg) and hepatitis B core-related antigen (HBcrAg), in the natural history of chronic hepatitis B (CHB) have not been well-characterized. Methods: Serum HQ-HBsAg and HBcrAg levels of 404 Asian treatment-naïve CHB patients were analyzed cross-sectionally. Patients were categorized into 5 groups: immune tolerant (IT-group, n=52), immune clearance (IC-group, n=105), hepatitis B e antigen (HBeAg)-negative hepatitis (ENH-group, n=97), HBeAg-negative quiescent group (ENQ-group, n=95) and CHB with hepatitis B surface antigen (HBsAg) seroclearance (SC-group, n=55). HQ-HBsAg and HBcrAg were measured and correlated with HBV DNA, HBsAg, HBV genotype and clinical parameters. Results: HQ-HBsAg showed good correlation with HBsAg, especially in the ENQ-group (r=0.874. p<0.001). Correlation of HQ-HBsAg with HBV DNA was less prominent and weakest in ENH-group (r=0.268, p=0.008). HBcrAg correlated best with HBV DNA in ENQ-group (r=0.537, p<0.001). 42.1% of ENQ-group patients had undetectable HBcrAg; this subgroup of patients, when compared to those with detectable HBcrAg, had significantly lower median HBV DNA (3.17/4.48 log IU/mL, p<0.001) and HBsAg (5.05/5.96 log mIU/mL, p<0.001) levels. 40% SC-group patients had detectable HQ-HBsAg and/or HBcrAg up to 42 months after HBsAg seroclearance. When comparing anti-HBs positivity and median time after HBsAg seroclearance in SC-group with and without detectable HQ-HBsAg/HBcrAg, there was no significant difference (22.7%/36.4% respectively, p=0.284 and 76.5/93.2 months respectively, p=0.245). Conclusion: HQ-HBsAg and HBcrAg showed unique patterns of distribution throughout the five disease phases of CHB, including high detectability rates after HBsAg seroclearance, opening up different possibilities for their applicability. |
Persistent Identifier | http://hdl.handle.net/10722/198547 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Seto, WKW | en_US |
dc.contributor.author | Wong, DKH | en_US |
dc.contributor.author | Fung, JYY | en_US |
dc.contributor.author | Huang, FY | en_US |
dc.contributor.author | Liu, KS | en_US |
dc.contributor.author | Lai, CL | en_US |
dc.contributor.author | Yuen, RMF | en_US |
dc.date.accessioned | 2014-07-07T07:17:11Z | - |
dc.date.available | 2014-07-07T07:17:11Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Clinical Microbiology and Infection, 2014, v. 20 n. 11, p. 1173-1180 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/198547 | - |
dc.description.abstract | Background: Changes in two novel HBV serologic markers, linearized hepatitis B surface antigen (HQ-HBsAg) and hepatitis B core-related antigen (HBcrAg), in the natural history of chronic hepatitis B (CHB) have not been well-characterized. Methods: Serum HQ-HBsAg and HBcrAg levels of 404 Asian treatment-naïve CHB patients were analyzed cross-sectionally. Patients were categorized into 5 groups: immune tolerant (IT-group, n=52), immune clearance (IC-group, n=105), hepatitis B e antigen (HBeAg)-negative hepatitis (ENH-group, n=97), HBeAg-negative quiescent group (ENQ-group, n=95) and CHB with hepatitis B surface antigen (HBsAg) seroclearance (SC-group, n=55). HQ-HBsAg and HBcrAg were measured and correlated with HBV DNA, HBsAg, HBV genotype and clinical parameters. Results: HQ-HBsAg showed good correlation with HBsAg, especially in the ENQ-group (r=0.874. p<0.001). Correlation of HQ-HBsAg with HBV DNA was less prominent and weakest in ENH-group (r=0.268, p=0.008). HBcrAg correlated best with HBV DNA in ENQ-group (r=0.537, p<0.001). 42.1% of ENQ-group patients had undetectable HBcrAg; this subgroup of patients, when compared to those with detectable HBcrAg, had significantly lower median HBV DNA (3.17/4.48 log IU/mL, p<0.001) and HBsAg (5.05/5.96 log mIU/mL, p<0.001) levels. 40% SC-group patients had detectable HQ-HBsAg and/or HBcrAg up to 42 months after HBsAg seroclearance. When comparing anti-HBs positivity and median time after HBsAg seroclearance in SC-group with and without detectable HQ-HBsAg/HBcrAg, there was no significant difference (22.7%/36.4% respectively, p=0.284 and 76.5/93.2 months respectively, p=0.245). Conclusion: HQ-HBsAg and HBcrAg showed unique patterns of distribution throughout the five disease phases of CHB, including high detectability rates after HBsAg seroclearance, opening up different possibilities for their applicability. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Clinical Microbiology and Infection | en_US |
dc.subject | HBV | - |
dc.subject | HBcrAg | - |
dc.subject | HBsAg | - |
dc.subject | HQ-HBsAg | - |
dc.subject | Serology | - |
dc.title | Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B | en_US |
dc.type | Article | en_US |
dc.identifier.email | Seto, WKW: wkseto2@hku.hk | en_US |
dc.identifier.email | Wong, DKH: danywong@hku.hk | en_US |
dc.identifier.email | Fung, JYY: jfung@hkucc.hku.hk | en_US |
dc.identifier.email | Huang, FY: camy@graduate.hku.hk | en_US |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_US |
dc.identifier.email | Yuen, RMF: mfyuen@hku.hk | en_US |
dc.identifier.authority | Seto, WKW=rp01659 | en_US |
dc.identifier.authority | Wong, DKH=rp00492 | en_US |
dc.identifier.authority | Fung, JYY=rp00518 | en_US |
dc.identifier.authority | Yuen, RMF=rp00479 | en_US |
dc.identifier.doi | 10.1111/1469-0691.12739 | - |
dc.identifier.scopus | eid_2-s2.0-84917675883 | - |
dc.identifier.hkuros | 230127 | en_US |
dc.identifier.isi | WOS:000346337000043 | - |