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- Publisher Website: 10.1177/0004867413487229
- Scopus: eid_2-s2.0-84884264576
- PMID: 23612934
- WOS: WOS:000329558100010
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Article: A 3-year retrospective cohort study of predictors of relapse in first-episode psychosis in Hong Kong
Title | A 3-year retrospective cohort study of predictors of relapse in first-episode psychosis in Hong Kong |
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Authors | |
Keywords | Early psychosis predictors rehospitalization relapse schizophrenia |
Issue Date | 2013 |
Citation | Australian and New Zealand Journal of Psychiatry, 2013, v. 47 n. 8, p. 746-753 How to Cite? |
Abstract | Objective: Relapses in psychosis are costly and may have irreversible consequences. Relapse prevention is thus critical in the treatment of schizophrenia. Apart from medication discontinuation, a consistent relapse predictor has not been identified due to limitations in previous studies. We aim to investigate relapse predictors in a large cohort of patients with first-episode psychosis. Method: This is a retrospective cohort study designed to evaluate relapses in first-episode psychosis patients in 3 years. A total of 1400 patients case records were retrieved from a hospital database. Potential relapse predictors including demographic variables, baseline clinical measures, medication adherence, and residual positive symptoms upon clinical stabilization were collected. Results: The cumulative relapse rates were 19.3% by year 1, 38.4% by year 2, and 48.1% by year 3. Multivariate Cox-proportional hazards regression analysis revealed that medication non-adherence, smoking, schizophrenia diagnosis, younger age, and shorter baseline hospitalization were associated with an increased risk of relapse in 3 years. Conclusions: Nearly half of patients relapsed after 3 years following their first-episode psychosis. Smoking as a predictor of relapse is an intriguing new finding supportive of a link between nicotinic receptors and the dopamine system. Their relationship deserves further investigations with potential clinical implications for relapse prevention. © 2013 The Royal Australian and New Zealand College of Psychiatrists. |
Persistent Identifier | http://hdl.handle.net/10722/192735 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.643 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hui, CL-M | en_US |
dc.contributor.author | Tang, JY-M | en_US |
dc.contributor.author | Leung, C-M | en_US |
dc.contributor.author | Wong, GH-Y | en_US |
dc.contributor.author | Chang, W-C | en_US |
dc.contributor.author | Chan, SK-W | en_US |
dc.contributor.author | Lee, EH-M | en_US |
dc.contributor.author | Chen, EY-H | en_US |
dc.date.accessioned | 2013-11-20T05:00:05Z | - |
dc.date.available | 2013-11-20T05:00:05Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Australian and New Zealand Journal of Psychiatry, 2013, v. 47 n. 8, p. 746-753 | en_US |
dc.identifier.issn | 0004-8674 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/192735 | - |
dc.description.abstract | Objective: Relapses in psychosis are costly and may have irreversible consequences. Relapse prevention is thus critical in the treatment of schizophrenia. Apart from medication discontinuation, a consistent relapse predictor has not been identified due to limitations in previous studies. We aim to investigate relapse predictors in a large cohort of patients with first-episode psychosis. Method: This is a retrospective cohort study designed to evaluate relapses in first-episode psychosis patients in 3 years. A total of 1400 patients case records were retrieved from a hospital database. Potential relapse predictors including demographic variables, baseline clinical measures, medication adherence, and residual positive symptoms upon clinical stabilization were collected. Results: The cumulative relapse rates were 19.3% by year 1, 38.4% by year 2, and 48.1% by year 3. Multivariate Cox-proportional hazards regression analysis revealed that medication non-adherence, smoking, schizophrenia diagnosis, younger age, and shorter baseline hospitalization were associated with an increased risk of relapse in 3 years. Conclusions: Nearly half of patients relapsed after 3 years following their first-episode psychosis. Smoking as a predictor of relapse is an intriguing new finding supportive of a link between nicotinic receptors and the dopamine system. Their relationship deserves further investigations with potential clinical implications for relapse prevention. © 2013 The Royal Australian and New Zealand College of Psychiatrists. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Australian and New Zealand Journal of Psychiatry | en_US |
dc.subject | Early psychosis | - |
dc.subject | predictors | - |
dc.subject | rehospitalization | - |
dc.subject | relapse | - |
dc.subject | schizophrenia | - |
dc.title | A 3-year retrospective cohort study of predictors of relapse in first-episode psychosis in Hong Kong | en_US |
dc.type | Article | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1177/0004867413487229 | en_US |
dc.identifier.pmid | 23612934 | - |
dc.identifier.scopus | eid_2-s2.0-84884264576 | en_US |
dc.identifier.hkuros | 214632 | - |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 746 | en_US |
dc.identifier.epage | 753 | en_US |
dc.identifier.isi | WOS:000329558100010 | - |
dc.identifier.issnl | 0004-8674 | - |