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- Publisher Website: 10.1109/EMBC.2012.6345960
- Scopus: eid_2-s2.0-84883565541
- PMID: 23365921
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Conference Paper: Tract-based spatial statistics (TBSS): application to detecting white matter tract variation in mild hypoxic-ischemic neonates
Title | Tract-based spatial statistics (TBSS): application to detecting white matter tract variation in mild hypoxic-ischemic neonates |
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Authors | |
Issue Date | 2012 |
Publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 |
Citation | The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 432-435 How to Cite? |
Abstract | The aim of this study is to employ tract-based spatial statistics (TBSS) to analyze the voxel-wise differences in DTI parameters between normal and mild hypoxic-ischemic (HI) neonatal brains. Forty-one full term neonates (24 normal controls and 17 with mild HI injury) and 31 preterm neonates (20 normal controls and 11 with mild HI injury) underwent T1 weighted imaging, T2 weighted imaging and diffusion tensor imaging (DTI) within 28 days after birth. The voxel differences of fractional anisotropy (FA), lambda1, lambda2, and lambda3 values between mild HI group and control group were analyzed in preterm and full term neonates respectively. The significantly decreased FA with increased lambda2, lambda3 in corticospinal tract, genu of corpus callosum (GCC), external capsule (EC) and splenium of the corpus callosum (SCC) in mild HI neonates suggested deficits or delays in both myelination and premyelination. Such impaired corticospinal tract, in both preterm and term neonates, may directly lead to the subsequent poor motor performance. Impaired EC and SCC, the additional injured sites observed in full term neonates with mild HI injury, may be causally responsible for the dysfunction in coordination and integration. In conclusion, TBSS provides an objective, independent and sensitive method for DTI data analysis of neonatal white matter alterations after mild HI injury. |
Persistent Identifier | http://hdl.handle.net/10722/191626 |
ISBN | |
ISSN | 2020 SCImago Journal Rankings: 0.282 |
DC Field | Value | Language |
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dc.contributor.author | Gao, J | en_US |
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Hou, X | en_US |
dc.contributor.author | Ding, A | en_US |
dc.contributor.author | Chan, KC | en_US |
dc.contributor.author | Sun, Q | en_US |
dc.contributor.author | Wu, EX | en_US |
dc.contributor.author | Yang, J | en_US |
dc.date.accessioned | 2013-10-15T07:14:44Z | - |
dc.date.available | 2013-10-15T07:14:44Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 432-435 | en_US |
dc.identifier.isbn | 978-1-4577-1787-1 | - |
dc.identifier.issn | 1557-170X | - |
dc.identifier.uri | http://hdl.handle.net/10722/191626 | - |
dc.description.abstract | The aim of this study is to employ tract-based spatial statistics (TBSS) to analyze the voxel-wise differences in DTI parameters between normal and mild hypoxic-ischemic (HI) neonatal brains. Forty-one full term neonates (24 normal controls and 17 with mild HI injury) and 31 preterm neonates (20 normal controls and 11 with mild HI injury) underwent T1 weighted imaging, T2 weighted imaging and diffusion tensor imaging (DTI) within 28 days after birth. The voxel differences of fractional anisotropy (FA), lambda1, lambda2, and lambda3 values between mild HI group and control group were analyzed in preterm and full term neonates respectively. The significantly decreased FA with increased lambda2, lambda3 in corticospinal tract, genu of corpus callosum (GCC), external capsule (EC) and splenium of the corpus callosum (SCC) in mild HI neonates suggested deficits or delays in both myelination and premyelination. Such impaired corticospinal tract, in both preterm and term neonates, may directly lead to the subsequent poor motor performance. Impaired EC and SCC, the additional injured sites observed in full term neonates with mild HI injury, may be causally responsible for the dysfunction in coordination and integration. In conclusion, TBSS provides an objective, independent and sensitive method for DTI data analysis of neonatal white matter alterations after mild HI injury. | - |
dc.language | eng | en_US |
dc.publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 | - |
dc.relation.ispartof | IEEE Engineering in Medicine and Biology Society Conference Proceedings | en_US |
dc.subject.mesh | Brain - pathology | - |
dc.subject.mesh | Diffusion Tensor Imaging - statistics and numerical data | - |
dc.subject.mesh | Hypoxia-Ischemia, Brain - diagnosis - pathology | - |
dc.subject.mesh | Image Interpretation, Computer-Assisted - methods | - |
dc.subject.mesh | Magnetic Resonance Imaging - statistics and numerical data | - |
dc.title | Tract-based spatial statistics (TBSS): application to detecting white matter tract variation in mild hypoxic-ischemic neonates | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wu, EX: ewu1@hkucc.hku.hk | en_US |
dc.identifier.authority | Wu, EX=rp00193 | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1109/EMBC.2012.6345960 | - |
dc.identifier.pmid | 23365921 | - |
dc.identifier.scopus | eid_2-s2.0-84883565541 | - |
dc.identifier.hkuros | 225958 | en_US |
dc.identifier.spage | 432 | - |
dc.identifier.epage | 435 | - |
dc.publisher.place | United States | en_US |
dc.customcontrol.immutable | sml 131107 | - |
dc.identifier.issnl | 1557-170X | - |