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Conference Paper: Methylation status at HPV16 E2 binding sites is a potential molecular marker for monitoring patients with Cervical Intraepithelial Neoplasia (CIN)
Title | Methylation status at HPV16 E2 binding sites is a potential molecular marker for monitoring patients with Cervical Intraepithelial Neoplasia (CIN) |
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Authors | |
Issue Date | 2012 |
Publisher | HPV2012. |
Citation | The 28th International Papillomavirus Conference (HPV 2012) & Clinical and Public Health Workshops, San Juan, Puerto Rico, Brazil, 30 November-6 December 2012. In HPV2012 Abstract Book: Clinical Sciences, 2012, p. 18 How to Cite? |
Abstract | OBJECTIVES: There are four E2 binding sites (E2BSs) at the LCR region of HPV16 genome. Binding of E2 protein to different E2BSs may exert either transcriptional activation/repression on E6 and E7 oncoprotein, depending on their distance from the TATA box of the promoter. Methylation status at the E2BSs may affect the relative binding of E2 protein to them and may change during cervical carcinogenesis. Such change in methylation status of the E2BSs may be a potential molecular mark... |
Description | Session - Clinical Sciences Biomarkers: New and improved for cancer prevention/management of disease |
Persistent Identifier | http://hdl.handle.net/10722/190113 |
DC Field | Value | Language |
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dc.contributor.author | Leung, TW | en_US |
dc.contributor.author | Liu, SS | en_US |
dc.contributor.author | Cheung, ANY | en_US |
dc.contributor.author | Ngan, HYS | en_US |
dc.date.accessioned | 2013-09-17T15:09:55Z | - |
dc.date.available | 2013-09-17T15:09:55Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | The 28th International Papillomavirus Conference (HPV 2012) & Clinical and Public Health Workshops, San Juan, Puerto Rico, Brazil, 30 November-6 December 2012. In HPV2012 Abstract Book: Clinical Sciences, 2012, p. 18 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/190113 | - |
dc.description | Session - Clinical Sciences Biomarkers: New and improved for cancer prevention/management of disease | - |
dc.description.abstract | OBJECTIVES: There are four E2 binding sites (E2BSs) at the LCR region of HPV16 genome. Binding of E2 protein to different E2BSs may exert either transcriptional activation/repression on E6 and E7 oncoprotein, depending on their distance from the TATA box of the promoter. Methylation status at the E2BSs may affect the relative binding of E2 protein to them and may change during cervical carcinogenesis. Such change in methylation status of the E2BSs may be a potential molecular mark... | - |
dc.language | eng | en_US |
dc.publisher | HPV2012. | - |
dc.relation.ispartof | HPV 2012 & Clinical & Public Health Workshops | en_US |
dc.title | Methylation status at HPV16 E2 binding sites is a potential molecular marker for monitoring patients with Cervical Intraepithelial Neoplasia (CIN) | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Liu, SS: stephasl@hku.hk | en_US |
dc.identifier.email | Cheung, ANY: anycheun@hkucc.hku.hk | en_US |
dc.identifier.email | Ngan, HYS: hysngan@hkucc.hku.hk | en_US |
dc.identifier.authority | Liu, SS=rp00372 | en_US |
dc.identifier.authority | Cheung, ANY=rp00542 | en_US |
dc.identifier.authority | Ngan, HYS=rp00346 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 223411 | en_US |
dc.identifier.spage | 18 | - |
dc.identifier.epage | 18 | - |
dc.publisher.place | Brazil | - |