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Article: Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression

TitleInduction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression
Authors
Chiu, LCMWan, JMF
KeywordsApoptosis
Bcl-2
Cell cycle
Eicosapentaenoic acid
Flow cytometry
Human leukemic cells
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 1999, v. 145 n. 1-2, p. 17-27 How to Cite?
DOI: http://dx.doi.org/10.1016/S0304-3835(99)00224-4
AbstractDietary polyunsaturated fatty acids (PUFAs) have been reported as a potential group of natural products which modulate tumor cell growth. In present study, eicosapentaenoic acid (EPA) was found to inhibit proliferation of human leukemic HL-60 and K-562 cells in vitro. EPA arrested cell cycle progression at G0/G1 phase, and induced necrosis in both HL-60 and K-562 cells. However, EPA induced apoptosis only in HL-60 but not K-562 cells. Also, bcl-2 protein expression was downregulated in much greater extent than that of bax showing that depression of bcl-2 might be an important step during the EPA-induced apoptosis in HL-60 cells.
Persistent Identifierhttp://hdl.handle.net/10722/178660
ISSN
0304-3835
2021 Impact Factor: 9.756
2020 SCImago Journal Rankings: 2.470
ISI Accession Number ID
WOS:000082705700003
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChiu, LCMen_US
dc.contributor.authorWan, JMFen_US
dc.date.accessioned2012-12-19T09:49:00Z-
dc.date.available2012-12-19T09:49:00Z-
dc.date.issued1999en_US
dc.identifier.citationCancer Letters, 1999, v. 145 n. 1-2, p. 17-27en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/178660-
dc.description.abstractDietary polyunsaturated fatty acids (PUFAs) have been reported as a potential group of natural products which modulate tumor cell growth. In present study, eicosapentaenoic acid (EPA) was found to inhibit proliferation of human leukemic HL-60 and K-562 cells in vitro. EPA arrested cell cycle progression at G0/G1 phase, and induced necrosis in both HL-60 and K-562 cells. However, EPA induced apoptosis only in HL-60 but not K-562 cells. Also, bcl-2 protein expression was downregulated in much greater extent than that of bax showing that depression of bcl-2 might be an important step during the EPA-induced apoptosis in HL-60 cells.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subjectApoptosis-
dc.subjectBcl-2-
dc.subjectCell cycle-
dc.subjectEicosapentaenoic acid-
dc.subjectFlow cytometry-
dc.subjectHuman leukemic cells-
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshDrug Screening Assays, Antitumoren_US
dc.subject.meshEicosapentaenoic Acid - Pharmacologyen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshG0 Phase - Drug Effectsen_US
dc.subject.meshG1 Phase - Drug Effectsen_US
dc.subject.meshHl-60 Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, Bcr-Abl Positive - Drug Therapy - Pathologyen_US
dc.subject.meshLeukemia, Promyelocytic, Acute - Drug Therapy - Pathologyen_US
dc.subject.meshProto-Oncogene Proteins C-Bcl-2 - Biosynthesisen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleInduction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expressionen_US
dc.typeArticleen_US
dc.identifier.emailWan, JMF: jmfwan@hku.hken_US
dc.identifier.authorityWan, JMF=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(99)00224-4en_US
dc.identifier.pmid10530765-
dc.identifier.scopuseid_2-s2.0-0032886232en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032886232&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume145en_US
dc.identifier.issue1-2en_US
dc.identifier.spage17en_US
dc.identifier.epage27en_US
dc.identifier.isiWOS:000082705700003-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridChiu, LCM=7103129041en_US
dc.identifier.scopusauthoridWan, JMF=8930305000en_US
dc.identifier.issnl0304-3835-

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