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Article: Oxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells

TitleOxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells
Authors
KeywordsBinding, competitive
Lipoproteins, LDL
Macrophages
Malondialdelhyde modification
Oxidative modification
Receptors, LDL
Issue Date1998
PublisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journal
Citation
British Journal Of Biomedical Science, 1998, v. 55 n. 3, p. 192-198 How to Cite?
AbstractComparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other.
Persistent Identifierhttp://hdl.handle.net/10722/178620
ISSN
2020 Impact Factor: 3.829
2015 SCImago Journal Rankings: 0.352
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Men_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorDing, Zen_US
dc.contributor.authorPang, Zen_US
dc.contributor.authorWan, Jen_US
dc.date.accessioned2012-12-19T09:48:45Z-
dc.date.available2012-12-19T09:48:45Z-
dc.date.issued1998en_US
dc.identifier.citationBritish Journal Of Biomedical Science, 1998, v. 55 n. 3, p. 192-198en_US
dc.identifier.issn0967-4845en_US
dc.identifier.urihttp://hdl.handle.net/10722/178620-
dc.description.abstractComparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other.en_US
dc.languageengen_US
dc.publisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journalen_US
dc.relation.ispartofBritish Journal of Biomedical Scienceen_US
dc.subjectBinding, competitive-
dc.subjectLipoproteins, LDL-
dc.subjectMacrophages-
dc.subjectMalondialdelhyde modification-
dc.subjectOxidative modification-
dc.subjectReceptors, LDL-
dc.subject.meshAnimalsen_US
dc.subject.meshCell Culture Techniquesen_US
dc.subject.meshEndothelium, Vascular - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLipoproteins, Ldl - Metabolismen_US
dc.subject.meshMacrophages, Peritoneal - Metabolismen_US
dc.subject.meshMalondialdehyde - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshOxidation-Reductionen_US
dc.titleOxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cellsen_US
dc.typeArticleen_US
dc.identifier.emailWan, J: jmfwan@hku.hken_US
dc.identifier.authorityWan, J=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10367404-
dc.identifier.scopuseid_2-s2.0-0031756156en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031756156&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume55en_US
dc.identifier.issue3en_US
dc.identifier.spage192en_US
dc.identifier.epage198en_US
dc.identifier.isiWOS:000076519700006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZhou, M=7403506134en_US
dc.identifier.scopusauthoridChen, Y=16745998900en_US
dc.identifier.scopusauthoridLiu, S=7409463469en_US
dc.identifier.scopusauthoridDing, Z=35247593000en_US
dc.identifier.scopusauthoridPang, Z=7103343225en_US
dc.identifier.scopusauthoridWan, J=8930305000en_US
dc.identifier.issnl0967-4845-

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