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Conference Paper: High ferritin and low transferrin saturation are associated with pre-diabetes among adults
Title | High ferritin and low transferrin saturation are associated with pre-diabetes among adults |
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Authors | |
Keywords | Cardiovascular disease |
Issue Date | 2012 |
Publisher | Hong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3 |
Citation | The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2012), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 51, abstract no. OP6 How to Cite? |
Abstract | BACKGROUND AND AIMS: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that is saturated with iron) with pre-diabetes (preDM) in US adults without chronic kidney disease, anemia, and iron deficiency. METHODS: Data on 2,575 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 who were free of diabetes, chronic kidney disease, iron deficiency, and anemia were analyzed. Data on 3,876 participants of the NHANES III (1988-1994) were used as replication. Homeostasis model assessment of insulin resistance (HOMA-IR), blood glycosylated hemoglobin level (A1C), fasting glucose, insulin, and preDM (defined as a fasting plasma glucose 100-125 mg/dl or an A1C value 5.7-6.4%) were measured as the outcomes. RESULTS: Logistic regression analyses indicated independent associations of high ferritin (Ptrend=0.028) and low TSAT (Ptrend=0.029) with preDM after adjusting for sociodemographics, physical activity (active/sedementary), metabolic and inflammatory markers (triglycerides, total cholesterol, HDL cholesterol, mean arterial pressure, CRP, white cell count, and albumin), and liver enzymes (GGT, ALP, AST, and ALT). The NHANES III data showed similar associations. Combining the results showed a more significant association for high ferritin (Pmeta=0.016) and low TSAT (Pmeta=0.002). Moreover, TSAT was associated with A1C, fasting glucose, insulin, and HOMA-IR (Pmeta ≤0.001). CONCLUSIONS: Higher ferritin and lower TSAT are associated with higher risk of preDM in a general population without confounding diseases. Further research is needed to examine the underlying mechanism of these two indices, especially TSAT, in the pathophysiology of preDM. |
Description | Oral Presentation Young Investigator Award Second Prize |
Persistent Identifier | http://hdl.handle.net/10722/177472 |
ISSN | 2023 SCImago Journal Rankings: 0.115 |
DC Field | Value | Language |
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dc.contributor.author | Cheung, CL | en_US |
dc.contributor.author | Cheung, TT | en_US |
dc.contributor.author | Lam, KSL | en_US |
dc.contributor.author | Cheung, BMY | en_US |
dc.date.accessioned | 2012-12-18T05:12:03Z | - |
dc.date.available | 2012-12-18T05:12:03Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2012), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 51, abstract no. OP6 | en_US |
dc.identifier.issn | 1027-7811 | - |
dc.identifier.uri | http://hdl.handle.net/10722/177472 | - |
dc.description | Oral Presentation | - |
dc.description | Young Investigator Award Second Prize | - |
dc.description.abstract | BACKGROUND AND AIMS: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that is saturated with iron) with pre-diabetes (preDM) in US adults without chronic kidney disease, anemia, and iron deficiency. METHODS: Data on 2,575 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 who were free of diabetes, chronic kidney disease, iron deficiency, and anemia were analyzed. Data on 3,876 participants of the NHANES III (1988-1994) were used as replication. Homeostasis model assessment of insulin resistance (HOMA-IR), blood glycosylated hemoglobin level (A1C), fasting glucose, insulin, and preDM (defined as a fasting plasma glucose 100-125 mg/dl or an A1C value 5.7-6.4%) were measured as the outcomes. RESULTS: Logistic regression analyses indicated independent associations of high ferritin (Ptrend=0.028) and low TSAT (Ptrend=0.029) with preDM after adjusting for sociodemographics, physical activity (active/sedementary), metabolic and inflammatory markers (triglycerides, total cholesterol, HDL cholesterol, mean arterial pressure, CRP, white cell count, and albumin), and liver enzymes (GGT, ALP, AST, and ALT). The NHANES III data showed similar associations. Combining the results showed a more significant association for high ferritin (Pmeta=0.016) and low TSAT (Pmeta=0.002). Moreover, TSAT was associated with A1C, fasting glucose, insulin, and HOMA-IR (Pmeta ≤0.001). CONCLUSIONS: Higher ferritin and lower TSAT are associated with higher risk of preDM in a general population without confounding diseases. Further research is needed to examine the underlying mechanism of these two indices, especially TSAT, in the pathophysiology of preDM. | - |
dc.language | eng | en_US |
dc.publisher | Hong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3 | - |
dc.relation.ispartof | Journal of the Hong Kong College of Cardiology | en_US |
dc.subject | Cardiovascular disease | - |
dc.title | High ferritin and low transferrin saturation are associated with pre-diabetes among adults | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Cheung, CL: lung1212@hku.hk | en_US |
dc.identifier.email | Cheung, TT: tcheungt@hku.hk | en_US |
dc.identifier.email | Lam, KSL: ksllam@hku.hk | en_US |
dc.identifier.email | Cheung, BMY: mycheung@hku.hk | en_US |
dc.identifier.authority | Cheung, TT=rp01682 | en_US |
dc.identifier.authority | Lam, KSL=rp00343 | en_US |
dc.identifier.authority | Cheung, BMY=rp01321 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 212521 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 51 | en_US |
dc.identifier.epage | 51 | en_US |
dc.publisher.place | Hong Kong | - |
dc.description.other | The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 51, abstract no. OP6 | - |
dc.identifier.issnl | 1027-7811 | - |