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  Patent History
  • Application
    US 10/841125 2004-05-07
  • Granted
    US 7521242 2009-04-21
Supplementary

granted patent: Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids

TitleHost cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids
Granted PatentUS 7521242
Granted Date2009-04-21
Priority Date2004-05-07 US 10/841125
2003-05-09 PCT/US2003014657
2003-05-09 US 10/469494P
Inventors
Issue Date2009
Citation
US Patent US 7521242. Washington, DC: US Patent and Trademark Office (USPTO), 2009 How to Cite?
AbstractMethods are disclosed herein for inducing homologous recombination in a host cell comprising a target nucleic acid, using a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule has a sufficient number of nucleotides homologous to the target nucleic acid to enable homologous recombination with the target nucleic acid. The host cell includes a de-repressible promoter operably linked to a nucleic acid encoding a single-stranded binding protein and is deficient for mismatch repair. Isolated host cells of use in this method are also disclosed.
Persistent Identifierhttp://hdl.handle.net/10722/177039

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:59Z-
dc.date.available2012-11-30T08:38:59Z-
dc.date.issued2009-
dc.identifier.citationUS Patent US 7521242. Washington, DC: US Patent and Trademark Office (USPTO), 2009en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177039-
dc.description.abstractMethods are disclosed herein for inducing homologous recombination in a host cell comprising a target nucleic acid, using a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule has a sufficient number of nucleotides homologous to the target nucleic acid to enable homologous recombination with the target nucleic acid. The host cell includes a de-repressible promoter operably linked to a nucleic acid encoding a single-stranded binding protein and is deficient for mismatch repair. Isolated host cells of use in this method are also disclosed.en_HK
dc.titleHost cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acidsen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorCourt Donald Len_HK
dc.contributor.inventorLi Xin-Tianen_HK
dc.contributor.inventorHuang, Jen_HK
dc.contributor.inventorCostantino Ninaen_HK
dc.contributor.inventorLiu Depeien_HK
patents.identifier.applicationUS 10/841125en_HK
patents.identifier.grantedUS 7521242en_HK
patents.description.assigneeUS HEALTH [US]en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.granted2009-04-21en_HK
patents.date.application2004-05-07en_HK
patents.date.priority2004-05-07 US 10/841125en_HK
patents.date.priority2003-05-09 PCT/US2003014657en_HK
patents.date.priority2003-05-09 US 10/469494Pen_HK
patents.description.ccUSen_HK
patents.relation.familyAU 2003228972 (A1) 2005-01-21en_HK
patents.relation.familyUS 2005079618 (A1) 2005-04-14en_HK
patents.relation.familyUS 7521242 (B2) 2009-04-21en_HK
patents.relation.familyWO 2004106513 (A1) 2004-12-09en_HK
patents.description.kindB2en_HK
patents.typePatent_granteden_HK

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