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Patent History
- ApplicationCA 20022380471 2002-03-27
- PublicationCA 2380471 2003-08-28
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published patent: ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION
Title | ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION |
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Priority Date | 2002-02-28 US 10/359945P |
Inventors | |
Issue Date | 2003 |
Citation | Canada Published Patent Application CA 2380471. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2003 How to Cite? |
Abstract | The present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestin al mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Giv en orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene( s) in the eurokaryotic environment, the viral products of which help to booster a cell - mediated immunity to clear the infection and reverse a state of immune tolerance characteristi c of HBV chronic infection. |
Persistent Identifier | http://hdl.handle.net/10722/176574 |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:38:08Z | - |
dc.date.available | 2012-11-30T08:38:08Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Canada Published Patent Application CA 2380471. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2003 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/176574 | - |
dc.description.abstract | The present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestin al mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Giv en orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene( s) in the eurokaryotic environment, the viral products of which help to booster a cell - mediated immunity to clear the infection and reverse a state of immune tolerance characteristi c of HBV chronic infection. | en_HK |
dc.title | ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | Yuen, KY | en_HK |
dc.contributor.inventor | Zheng, B | en_HK |
dc.contributor.inventor | Ng, Mun-Hon | en_HK |
patents.identifier.application | CA 20022380471 | en_HK |
patents.description.assignee | UNIV HONG KONG [HK] | en_HK |
patents.description.country | Canada | en_HK |
patents.date.publication | 2003-08-28 | en_HK |
patents.date.application | 2002-03-27 | en_HK |
patents.date.priority | 2002-02-28 US 10/359945P | en_HK |
patents.description.cc | CA | en_HK |
patents.identifier.publication | CA 2380471 | en_HK |
patents.relation.family | AU 2003210122 (A1) 2003-09-09 | en_HK |
patents.relation.family | CA 2380471 (A1) 2003-08-28 | en_HK |
patents.relation.family | CN 1444996 (A) 2003-10-01 | en_HK |
patents.relation.family | CN 100528238 (C) 2009-08-19 | en_HK |
patents.relation.family | HK 1058144 (A1) 2010-04-23 | en_HK |
patents.relation.family | US 2003162741 (A1) 2003-08-28 | en_HK |
patents.relation.family | US 2006228374 (A1) 2006-10-12 | en_HK |
patents.relation.family | WO 03072012 (A2) 2003-09-04 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |