File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s00380-007-0993-x
- Scopus: eid_2-s2.0-36749075699
- PMID: 18043998
- WOS: WOS:000251235900008
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Plasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedure
Title | Plasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedure |
---|---|
Authors | |
Keywords | Brain natriuretic peptide Fontan procedure Ventricular function |
Issue Date | 2007 |
Publisher | Springer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327 |
Citation | Heart And Vessels, 2007, v. 22 n. 6, p. 398-403 How to Cite? |
Abstract | While increased plasma brain natriuretic peptide (BNP) levels have been documented late after the Fontan procedure, its significance remains unclear. We sought to test the hypothesis that plasma BNP levels reflect systemic ventricular function after the Fontan procedure by interrogating the relationship between plasma BNP level and indices of ventricular function. The plasma BNP levels and systemic ventricular function, as determined by conventional and tissue Doppler assessments, acoustic quantification (AQ), and myocardial performance index (MPI), of 35 asymptomatic Fontan patients were compared to those of 34 control subjects who had previous repair of ventricular septal defect. When compared with controls, Fontan patients had significantly higher plasma BNP levels (median 21pg/ml, range 5-397 vs median 15pg/ml, range 5-62, P = 0.04). Their systolic and diastolic ventricular function was impaired as evidenced by reduced systemic ventricular early diastolic (E) inflow velocity, early to late (A) diastolic inflow velocity ratio, left and right annular early diastolic (e), late diastolic (a), and systolic (s) velocities, AQ-derived ventricular fractional area change, peak emptying rate, and peak filling rate, and increased AQ-derived atrial filling fraction and MPI (all P < 0.05). Plasma BNP levels correlated negatively with E and A velocities, left-sided annular a velocity, and right-sided annular e, a, and s velocities, and positively with AQ-derived atrial filling fraction (all P < 0.05). In conclusion, our findings suggest that plasma BNP levels reflect primarily the diastolic function of the systemic ventricle in asymptomatic Fontan patients. © Springer-Verlag Tokyo 2007. |
Persistent Identifier | http://hdl.handle.net/10722/170390 |
ISSN | 2023 Impact Factor: 1.4 2023 SCImago Journal Rankings: 0.574 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Man, BL | en_US |
dc.contributor.author | Cheung, YF | en_US |
dc.date.accessioned | 2012-10-30T06:07:58Z | - |
dc.date.available | 2012-10-30T06:07:58Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Heart And Vessels, 2007, v. 22 n. 6, p. 398-403 | en_US |
dc.identifier.issn | 0910-8327 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170390 | - |
dc.description.abstract | While increased plasma brain natriuretic peptide (BNP) levels have been documented late after the Fontan procedure, its significance remains unclear. We sought to test the hypothesis that plasma BNP levels reflect systemic ventricular function after the Fontan procedure by interrogating the relationship between plasma BNP level and indices of ventricular function. The plasma BNP levels and systemic ventricular function, as determined by conventional and tissue Doppler assessments, acoustic quantification (AQ), and myocardial performance index (MPI), of 35 asymptomatic Fontan patients were compared to those of 34 control subjects who had previous repair of ventricular septal defect. When compared with controls, Fontan patients had significantly higher plasma BNP levels (median 21pg/ml, range 5-397 vs median 15pg/ml, range 5-62, P = 0.04). Their systolic and diastolic ventricular function was impaired as evidenced by reduced systemic ventricular early diastolic (E) inflow velocity, early to late (A) diastolic inflow velocity ratio, left and right annular early diastolic (e), late diastolic (a), and systolic (s) velocities, AQ-derived ventricular fractional area change, peak emptying rate, and peak filling rate, and increased AQ-derived atrial filling fraction and MPI (all P < 0.05). Plasma BNP levels correlated negatively with E and A velocities, left-sided annular a velocity, and right-sided annular e, a, and s velocities, and positively with AQ-derived atrial filling fraction (all P < 0.05). In conclusion, our findings suggest that plasma BNP levels reflect primarily the diastolic function of the systemic ventricle in asymptomatic Fontan patients. © Springer-Verlag Tokyo 2007. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327 | en_US |
dc.relation.ispartof | Heart and Vessels | en_US |
dc.subject | Brain natriuretic peptide | - |
dc.subject | Fontan procedure | - |
dc.subject | Ventricular function | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Echocardiography, Doppler | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fontan Procedure - Adverse Effects | en_US |
dc.subject.mesh | Heart Failure, Diastolic - Ultrasonography | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Natriuretic Peptide, Brain - Blood | en_US |
dc.subject.mesh | Ventricular Dysfunction, Left - Blood - Etiology - Ultrasonography | en_US |
dc.subject.mesh | Ventricular Function, Left | en_US |
dc.title | Plasma brain natriuretic peptide and systemic ventricular function in asymptomatic patients late after the Fontan procedure | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheung, YF:xfcheung@hku.hk | en_US |
dc.identifier.authority | Cheung, YF=rp00382 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s00380-007-0993-x | en_US |
dc.identifier.pmid | 18043998 | - |
dc.identifier.scopus | eid_2-s2.0-36749075699 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-36749075699&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 398 | en_US |
dc.identifier.epage | 403 | en_US |
dc.identifier.isi | WOS:000251235900008 | - |
dc.publisher.place | Japan | en_US |
dc.identifier.scopusauthorid | Man, BL=36770209000 | en_US |
dc.identifier.scopusauthorid | Cheung, YF=7202111067 | en_US |
dc.identifier.issnl | 0910-8327 | - |