Electrophysiologic assessment of (central) auditory processing disorder in children with non-syndromic cleft lip and/or palate

Abstract

Cleft of the lip and/or palate is a common congenital craniofacial malformation worldwide, particularly non-syndromic cleft lip and/or palate (NSCL/P). Though middle ear deficits in this population have been universally noted in numerous studies, other auditory problems including inner ear deficits or cortical dysfunction are rarely reported. A higher prevalence of educational problems has been noted in children with NSCL/P compared to craniofacially normal children. These high level cognitive difficulties cannot be entirely attributed to peripheral hearing loss. Recently it has been suggested that children with NSCLP may be more prone to abnormalities in the auditory cortex. The aim of the present study was to investigate whether school age children with (NSCL/P) have a higher prevalence of indications of (central) auditory processing disorder [(C)APD] compared to normal age matched controls when assessed using auditory event-related potential (ERP) techniques. School children (6 to 15 years) with NSCL/P and normal controls with matched age and gender were recruited. Auditory ERP recordings included auditory brainstem response and late event-related potentials, including the P1-N1-P2 complex and P300 waveforms. Initial findings from the present study are presented and their implications for further research in this area —and clinical intervention—are outlined. © 2012 Acoustical Society of America