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Article: Loss of heterozygosity on chromosome 11 in esophageal squamous cell carcinomas

TitleLoss of heterozygosity on chromosome 11 in esophageal squamous cell carcinomas
Authors
Lam, CTTang, CMCLau, KWLung, ML
KeywordsChromosome 11
Esophageal cancer
Loss of heterozygosity
Issue Date2002
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2002, v. 178 n. 1, p. 75-81 How to Cite?
DOI: http://dx.doi.org/10.1016/S0304-3835(01)00814-X
AbstractEsophageal cancer (ESC) is an important cancer worldwide. Chromosome 11 plays an important role in the development of several human cancers. In this study, 19 polymorphic microsatellite markers spanning the whole chromosome 11 were used to screen for loss of heterozygosity (LOH) in 38 primary esophageal squamous cell carcinomas. Thirty-three of 38 samples (86.8%) showed LOH at one or more loci. High frequencies (51.9-61.1%) of allelic loss were observed at D11S1338, D11S2000, D11S1990, and D11S1647 loci, in two chromosomal regions, 11p15.5 and 11q22.3. The results of this study suggest the presence of putative tumor suppressor genes in these two regions on chromosome 11 related to ESC. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150770
ISSN
0304-3835
2021 Impact Factor: 9.756
2020 SCImago Journal Rankings: 2.470
ISI Accession Number ID
WOS:000176995500010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLam, CTen_US
dc.contributor.authorTang, CMCen_US
dc.contributor.authorLau, KWen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:10:07Z-
dc.date.available2012-06-26T06:10:07Z-
dc.date.issued2002en_US
dc.identifier.citationCancer Letters, 2002, v. 178 n. 1, p. 75-81en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/150770-
dc.description.abstractEsophageal cancer (ESC) is an important cancer worldwide. Chromosome 11 plays an important role in the development of several human cancers. In this study, 19 polymorphic microsatellite markers spanning the whole chromosome 11 were used to screen for loss of heterozygosity (LOH) in 38 primary esophageal squamous cell carcinomas. Thirty-three of 38 samples (86.8%) showed LOH at one or more loci. High frequencies (51.9-61.1%) of allelic loss were observed at D11S1338, D11S2000, D11S1990, and D11S1647 loci, in two chromosomal regions, 11p15.5 and 11q22.3. The results of this study suggest the presence of putative tumor suppressor genes in these two regions on chromosome 11 related to ESC. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subjectChromosome 11-
dc.subjectEsophageal cancer-
dc.subjectLoss of heterozygosity-
dc.subject.meshAgeden_US
dc.subject.meshAlcohol Drinking - Adverse Effectsen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 11 - Geneticsen_US
dc.subject.meshEsophageal Neoplasms - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshHumansen_US
dc.subject.meshLoss Of Heterozygosity - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Metastasis - Geneticsen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.subject.meshSurvival Rateen_US
dc.titleLoss of heterozygosity on chromosome 11 in esophageal squamous cell carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(01)00814-Xen_US
dc.identifier.pmid11849744-
dc.identifier.scopuseid_2-s2.0-0037041277en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037041277&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume178en_US
dc.identifier.issue1en_US
dc.identifier.spage75en_US
dc.identifier.epage81en_US
dc.identifier.isiWOS:000176995500010-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLam, CT=7402989860en_US
dc.identifier.scopusauthoridTang, CMC=8274797200en_US
dc.identifier.scopusauthoridLau, KW=35080643000en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.issnl0304-3835-

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