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Article: Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas

TitleFrequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas
Authors
Ko, JMYWong, CPSTang, CMCLau, KWLung, ML
KeywordsChinese
Esophageal cancer
Loss of heterozygosity
Tumor suppressor genes
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2001, v. 170 n. 2, p. 131-138 How to Cite?
DOI: http://dx.doi.org/10.1016/S0304-3835(01)00577-8
AbstractAnalysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC development. The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150761
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000170505100004
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKo, JMYen_US
dc.contributor.authorWong, CPSen_US
dc.contributor.authorTang, CMCen_US
dc.contributor.authorLau, KWen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:10:00Z-
dc.date.available2012-06-26T06:10:00Z-
dc.date.issued2001en_US
dc.identifier.citationCancer Letters, 2001, v. 170 n. 2, p. 131-138en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/150761-
dc.description.abstractAnalysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC development. The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters. © 2001 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subjectChinese-
dc.subjectEsophageal cancer-
dc.subjectLoss of heterozygosity-
dc.subjectTumor suppressor genes-
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomesen_US
dc.subject.meshEsophageal Neoplasms - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleFrequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(01)00577-8en_US
dc.identifier.pmid11463490-
dc.identifier.scopuseid_2-s2.0-0035922190en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035922190&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume170en_US
dc.identifier.issue2en_US
dc.identifier.spage131en_US
dc.identifier.epage138en_US
dc.identifier.isiWOS:000170505100004-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridKo, JMY=35725559400en_US
dc.identifier.scopusauthoridWong, CPS=15745721700en_US
dc.identifier.scopusauthoridTang, CMC=8274797200en_US
dc.identifier.scopusauthoridLau, KW=35080643000en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.issnl0304-3835-

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