P53 inactivating mutations in Chinese breast carcinomas

Abstract

While previous reports on breast cancers indicate that Caucasian women have a low frequency of p53 mutations, higher frequencies of mutations are reported in some Japanese populations. There are few reports regarding p53 mutations in Chinese breast carcinomas. Using a previously established sensitive p53 yeast functional assay, we screened 23 Chinese breast carcinomas for mutations. The p53 was mutated in 5/23 (21.7%) specimens. Two of these mutations were detected in exon 5 and one was detected in each of exons 6, 7 and 8. All of these mutations have previously been shown to be mutated in Caucasian and Japanese breast cancers, but two have not previously been observed in Chinese breast cancers and one has also not been observed in Japanese. p53, mutation, Chinese breast cancer.